dipyridamole   Click here for help

GtoPdb Ligand ID: 4807

Synonyms: Persantine®
Approved drug PDB Ligand
dipyridamole is an approved drug (FDA (1961))
Compound class: Synthetic organic
Comment: Dipyridamole is a phosphodiesterase (PDE) inhibitor.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: dipyridamole, dipyridamole

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 12
Hydrogen bond donors 4
Rotatable bonds 12
Topological polar surface area 145.44
Molecular weight 504.32
XLogP 1.76
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCCN(c1nc(N2CCCCC2)c2c(n1)c(nc(n2)N(CCO)CCO)N1CCCCC1)CCO
Isomeric SMILES OCCN(c1nc(N2CCCCC2)c2c(n1)c(nc(n2)N(CCO)CCO)N1CCCCC1)CCO
InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChI Key IZEKFCXSFNUWAM-UHFFFAOYSA-N
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
phosphodiesterase 7B Hs Inhibitor Inhibition 5.7 – 6.0 pIC50 - 3,7
⤷ pIC50 5.7 – 6.0 (IC50 1.99x10-6 – 1x10-6 M) [3,7]
phosphodiesterase 8A Hs Inhibitor Inhibition 5.1 pIC50 - 2
⤷ pIC50 5.1 (IC50 7.94x10-6 M) [2]
phosphodiesterase 8B Hs Inhibitor Inhibition 4.3 pIC50 - 6
⤷ pIC50 4.3 (IC50 5.01x10-5 M) [6]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Equilibrative nucleoside transporter 1 Primary target of this compound Hs Inhibitor Inhibition 8.8 pKi - 5
⤷ pKi 8.8 (Ki 1.5x10-9 M) [5]
Plasma membrane monoamine transporter Hs Inhibitor Inhibition 5.9 pKi - 9
⤷ pKi 5.9 [9]
Targets where the ligand is described in the comment field
Target Comment
Equilibrative nucleoside transporter 1 SLC29A1 (ENT1) has 100-1000-fold lower affinity for nucleobases as compared with nucleosides [12]. The affinities of draflazine, dilazep, KF24345 and dipyridamole at SLC29A1 transporters are species dependent, exhibiting lower affinity at rat transporters than at human transporters [5,8]. Dilazep and nitrobenzylmercaptopurine ribonucleoside have distinct but overlapping binding domains in the SLC29A1 crystal structure [11]. The loss of SLC29A1 activity in SLC29A1-null mice has been associated with a hypermineralization disorder similar to human diffuse idiopathic skeletal hyperostosis [10]. Lack of SLC29A1 also results in the Augustine-null blood type [1]. SLC29A1 forms homodimers and heterodimers (with SLC29A2) [4].
Ligand mentioned in the following text fields
Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) comments