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Target not currently curated in GtoImmuPdb
Target id: 1306
Nomenclature: phosphodiesterase 7B
Abbreviated Name: PDE7B
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 450 | 6q23.3 | PDE7B | phosphodiesterase 7B | |
Mouse | - | 446 | 10 A3 | Pde7b | phosphodiesterase 7B | |
Rat | - | - | 1p12 | Pde7b | phosphodiesterase 7B |
Previous and Unofficial Names |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
Database Links | |
Alphafold | Q9NP56 (Hs), Q9QXQ1 (Mm) |
BRENDA | 3.1.4.17 |
CATH/Gene3D | 1.10.1300.10 |
ChEMBL Target | CHEMBL4716 (Hs) |
DrugBank Target | Q9NP56 (Hs) |
Ensembl Gene | ENSG00000171408 (Hs), ENSMUSG00000019990 (Mm), ENSRNOG00000013436 (Rn) |
Entrez Gene | 27115 (Hs), 29863 (Mm), 140929 (Rn) |
Human Protein Atlas | ENSG00000171408 (Hs) |
KEGG Enzyme | 3.1.4.17 |
KEGG Gene | hsa:27115 (Hs), mmu:29863 (Mm), rno:140929 (Rn) |
OMIM | 604645 (Hs) |
Pharos | Q9NP56 (Hs) |
UniProtKB | Q9NP56 (Hs), Q9QXQ1 (Mm) |
Wikipedia | PDE7B (Hs) |
Enzyme Reaction | ||||
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Rank order of affinity (Human) |
cyclic AMP >> cyclic GMP [2] |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Alaamery MA, Wyman AR, Ivey FD, Allain C, Demirbas D, Wang L, Ceyhan O, Hoffman CS. (2010) New classes of PDE7 inhibitors identified by a fission yeast-based HTS. J Biomol Screen, 15 (4): 359-67. [PMID:20228279]
2. Gardner C, Robas N, Cawkill D, Fidock M. (2000) Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun, 272 (1): 186-92. [PMID:10872825]
3. Sasaki T, Kotera J, Yuasa K, Omori K. (2000) Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun, 271 (3): 575-83. [PMID:10814504]