Cu2+   Click here for help

GtoPdb Ligand ID: 4164

Synonyms: copper ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
glycine receptor α1 subunit
glycine receptor α2 subunit
glycine receptor α3 subunit
ZAC
Cofactor in Enzyme Reactions
Enzyme Reference
Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
DMT1
Solute carrier family 41 member 1 2
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPA1 Mm Activator Activation 6.2 pEC50 - 1,3
⤷ pEC50 6.2 (EC50 6x10-7 M) [1,3]
TRPA1 Hs Activator Activation 5.9 pEC50 - 1,3
⤷ pEC50 5.9 (EC50 1.3x10-6 M) [1,3]
Description: Sodium imaging
Conditions: CHO cells expressing human TRPA1
ZAC Ligand is endogenous in the given species Hs Agonist Agonist 5.4 pEC50 - 4
⤷ pEC50 5.4 [4]
glycine receptor α1 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition 4.8 – 5.4 pIC50 -
⤷ pIC50 4.8 – 5.4 (IC50 1.5x10-5 – 4x10-6 M) endogenous; not affected by β subunit co-expression
glycine receptor α3 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition 5.0 pIC50 -
⤷ pIC50 5.0 (IC50 9x10-6 M) endogenous
glycine receptor α2 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition 4.8 pIC50 -
⤷ pIC50 4.8 (IC50 1.7x10-5 M) endogenous
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Other channel blockers at TRPV5 Pb2+ = Cu2+ = Gd3+ > Cd2+ > Zn2+ > La3+ > Co2+ > Fe2
Ligand mentioned in the following text fields
ZAC overview
ZAC comments