Cu2+   Click here for help

GtoPdb Ligand ID: 4164

Synonyms: copper ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Andersson DA, Gentry C, Moss S, Bevan S. (2009)
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
Proc Natl Acad Sci USA, 106 (20): 8374-9. [PMID:19416844]
2. Goytain A, Quamme GA. (2005)
Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters.
Physiol Genomics, 21 (3): 337-42. [PMID:15713785]
3. Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M, Ohta T. (2013)
Involvement of TRPA1 activation in acute pain induced by cadmium in mice.
Mol Pain, 9: 7. [PMID:23448290]
4. Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. (2016)
Copper and protons directly activate the zinc-activated channel.
Biochem Pharmacol, 103: 109-17. [PMID:26872532]