elafin   Click here for help

GtoPdb Ligand ID: 12035

Synonyms: cementoin | trappin-2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: Elafin is a protease inhibitor and it is an endogenous antimicrobial peptide. It is a component of the innate immune response and contributes to controlling microbial infection in mucosal surfaces [1,3-6]. Therapeutic potential of elafin and its precursor trappin-2 is discussed by Deraison et al. (2022) [2].
Species: Human
Bioactivity Comments
Elafin inhibits the elastase proteolytic activity of chymotrypsin like elastase 2A (CELA2).
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
chymotrypsin like elastase 2A Ligand is endogenous in the given species Hs Inhibitor Inhibition - - -
⤷