elafin

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Ligands
elafin (Human)

GtoPdb Ligand ID: 12035

Synonyms: cementoin | trappin-2

Compound class: Endogenous peptide in human, mouse or rat

Comment: Elafin is a protease inhibitor and it is an endogenous antimicrobial peptide. It is a component of the innate immune response and contributes to controlling microbial infection in mucosal surfaces [1,3-6]. Therapeutic potential of elafin and its precursor trappin-2 is discussed by Deraison et al. (2022) [2].

Species: Human

References
1. Afacan B, Öztürk VÖ, Emingil G, Köse T, Bostanci N. (2018) Alarm anti-protease trappin-2 negatively correlates with proinflammatory cytokines in patients with periodontitis. J Periodontol, 89 (1): 58-66. [PMID:28777039]
2. Deraison C, Bonnart C, Langella P, Roget K, Vergnolle N. (2023) Elafin and its precursor trappin-2: What is their therapeutic potential for intestinal diseases?. Br J Pharmacol, 180 (2): 144-160. [PMID:36355635]
3. Small DM, Doherty DF, Dougan CM, Weldon S, Taggart CC. (2017) The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease. Biol Chem, 398 (4): 425-440. [PMID:27930359]
4. Stock SJ, Kelly RW, Riley SC, Calder AA. (2007) Natural antimicrobial production by the amnion. Am J Obstet Gynecol, 196 (3): 255.e1-6. [PMID:17346544]
5. Verrier T, Solhonne B, Sallenave JM, Garcia-Verdugo I. (2012) The WAP protein Trappin-2/Elafin: a handyman in the regulation of inflammatory and immune responses. Int J Biochem Cell Biol, 44 (8): 1377-80. [PMID:22634606]
6. Wilkinson TS, Roghanian A, Simpson AJ, Sallenave JM. (2011) WAP domain proteins as modulators of mucosal immunity. Biochem Soc Trans, 39 (5): 1409-15. [PMID:21936824]

References

1. Afacan B, Öztürk VÖ, Emingil G, Köse T, Bostanci N. (2018)
Alarm anti-protease trappin-2 negatively correlates with proinflammatory cytokines in patients with periodontitis.
J Periodontol, 89 (1): 58-66. [PMID:28777039]

2. Deraison C, Bonnart C, Langella P, Roget K, Vergnolle N. (2023)
Elafin and its precursor trappin-2: What is their therapeutic potential for intestinal diseases?.
Br J Pharmacol, 180 (2): 144-160. [PMID:36355635]

3. Small DM, Doherty DF, Dougan CM, Weldon S, Taggart CC. (2017)
The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease.
Biol Chem, 398 (4): 425-440. [PMID:27930359]

4. Stock SJ, Kelly RW, Riley SC, Calder AA. (2007)
Natural antimicrobial production by the amnion.
Am J Obstet Gynecol, 196 (3): 255.e1-6. [PMID:17346544]

5. Verrier T, Solhonne B, Sallenave JM, Garcia-Verdugo I. (2012)
The WAP protein Trappin-2/Elafin: a handyman in the regulation of inflammatory and immune responses.
Int J Biochem Cell Biol, 44 (8): 1377-80. [PMID:22634606]

6. Wilkinson TS, Roghanian A, Simpson AJ, Sallenave JM. (2011)
WAP domain proteins as modulators of mucosal immunity.
Biochem Soc Trans, 39 (5): 1409-15. [PMID:21936824]