TAK-715 [Ligand Id: 9328] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL363648 (Tak-715, TAK 715, TAK-715) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
| ChEMBL | Inhibitory concentration against c-Jun N-terminal kinase 1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
| ChEMBL | Inhibitory concentration against I-kappa-B kinase beta | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase 3 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibition of recombinant human FLAG-tagged p38alpha expressed in baculovirus expression system using GFP-ATF2 (19 to 96 residues) as substrate preincubated for 5 mins followed by ATP addition measured after 20 mins by TR-FRET assay | B | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem (2018) 26: 647-660 [PMID:29291937] |
| ChEMBL | Displacement of SKF86002 from recombinant human p38alpha by fluorescence-based assay | B | 7.15 | pIC50 | 71 | nM | IC50 | Medchemcomm (2013) 4: 371-377 |
| ChEMBL | In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha | B | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| ChEMBL | Inhibition of p38 alpha (unknown origin) | B | 8.15 | pIC50 | 7.1 | nM | IC50 | Eur J Med Chem (2021) 215: 113277-113277 [PMID:33601311] |
| GtoPdb | - | - | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (2005) 48: 5966-79 [PMID:16162000] |
| mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase p38-beta | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| GtoPdb | - | - | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2005) 48: 5966-79 [PMID:16162000] |
| mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase p38-delta | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase p38-gamma | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233] | ||||||||
| ChEMBL | Inhibitory concentration against Mitogen-activated protein kinase kinase kinase 1 (MEKK1) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
| ChEMBL | Inhibitory concentration against Mitogen-activated protein kinase kinase kinase 7 (TAK1) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
