AM7 [Ligand Id: 8292] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL505896
  • protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
Created with Highcharts 10.3.3ValuesChart context menucAMP-dependent protein kinase alpha-catalytic subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
Created with Highcharts 10.3.3ValuesChart context menuc-Jun N-terminal kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
Created with Highcharts 10.3.3ValuesChart context menuCyclin-dependent kinase 5pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
Created with Highcharts 10.3.3ValuesChart context menuEpidermal growth factor receptor erbB1pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
Created with Highcharts 10.3.3ValuesChart context menuFibroblast growth factor receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
Created with Highcharts 10.3.3ValuesChart context menuHepatocyte growth factor receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
Created with Highcharts 10.3.3ValuesChart context menuMacrophage colony stimulating factor receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912]
Created with Highcharts 10.3.3ValuesChart context menuMacrophage-stimulating protein receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
Created with Highcharts 10.3.3ValuesChart context menuMAP kinase ERK1pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
Created with Highcharts 10.3.3ValuesChart context menuRibosomal protein S6 kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
Created with Highcharts 10.3.3ValuesChart context menuRibosomal protein S6 kinase alpha 5pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase AKTpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Aurora-ApKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase PIM1pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase PIM2pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase BTKpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase JAK2pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase JAK3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase LCKpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase TIE-2pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase ZAP-70pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
Created with Highcharts 10.3.3ValuesChart context menuVascular endothelial growth factor receptor 1pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
Created with Highcharts 10.3.3ValuesChart context menuVascular endothelial growth factor receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
Created with Highcharts 10.3.3ValuesChart context menuVascular endothelial growth factor receptor 3pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
ChEMBL Inhibition of PKAalpha B 4 pIC50 >100000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL Inhibition of JNK2 B 4 pIC50 >100000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
ChEMBL Inhibition of CDK5 B 4 pIC50 >100000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR B 5.77 pIC50 1700 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
ChEMBL Inhibition of FGFRK2 B 6 pIC50 >1000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Inhibition of cMet by HTRF assay B 8.05 pKi 8.9 nM Ki J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
ChEMBL Inhibition of human c-MET B 7.77 pIC50 17 nM IC50 Eur J Med Chem (2011) 46: 3675-3680 [PMID:21641696]
GtoPdb - - 7.77 pIC50 17 nM IC50 J Biol Chem (2008) 283: 2675-83 [PMID:18055465]
ChEMBL Inhibition of c-Met by HTRF assay B 8 pIC50 10 nM IC50 J Med Chem (2008) 51: 2879-2882 [PMID:18426196]
ChEMBL Inhibition of wild type GST-tagged c-Met kinase domain (1058 to 1365) (unknown origin) expressed in Sf9 cells by HTRF assay B 8.05 pIC50 8.9 nM IC50 Bioorg Med Chem (2013) 21: 2843-2855 [PMID:23628470]
ChEMBL Inhibition of c-Met (unknown origin) B 8.05 pIC50 8.9 nM IC50 Eur J Med Chem (2013) 64: 62-73 [PMID:23644189]
ChEMBL Inhibition of c-Met (unknown origin) B 8.05 pIC50 8.9 nM IC50 Eur J Med Chem (2014) 83: 581-593 [PMID:24996144]
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
ChEMBL Inhibition of cFMS kinase B 7.43 pIC50 37 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912]
ChEMBL Inhibition of phosphorylated RON B 6.71 pKi 195 nM Ki J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL Inhibition of ERK1 B 4 pIC50 >100000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
ChEMBL Inhibition of P70S6 B 5 pIC50 10000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
ChEMBL Inhibition of MSK1 B 4 pIC50 >100000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL Inhibition of PKBalpha B 4 pIC50 >100000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Inhibition of Aurora2 B 6.94 pIC50 116 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Inhibition of PIM1 kinase B 4.52 pIC50 >30000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
ChEMBL Inhibition of PIM2 kinase B 4.6 pIC50 >25000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
ChEMBL Inhibition of BTK B 7.72 pIC50 19 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Inhibition of JAK2 B 4.6 pIC50 >25000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL Inhibition of JAK3 B 5.08 pIC50 >8300 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL Inhibition of LCK B 8.1 pIC50 8 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
ChEMBL Inhibition of Tie2 kinase B 6.55 pIC50 285 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Inhibition of ZAP70 B 5.27 pIC50 >5400 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL Inhibition of Flt1 kinase B 6 pIC50 >1000 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of phosphorylated KDR by HTRF assay B 6.37 pKi 422 nM Ki J Med Chem (2008) 51: 5766-5779 [PMID:18763753]
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
ChEMBL Inhibition of Flt4 kinase B 6.92 pIC50 120 nM IC50 J Med Chem (2008) 51: 5766-5779 [PMID:18763753]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]