CEP-11981 [Ligand Id: 8189] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2010872
  • fibroblast growth factor receptor 1 in Human [GtoPdb: 1808] [UniProtKB: P11362]
  • This target only has 0 pki data point
  • 0
1 CHEMBL2010872_lig_chart_1 fibroblast growth factor receptor 1 Human
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  • fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948]
  • This target only has 0 pki data point
  • 0
2 CHEMBL2010872_lig_chart_2 fms related receptor tyrosine kinase 1 Human
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  • kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
  • This target only has 0 pki data point
  • 0
3 CHEMBL2010872_lig_chart_3 kinase insert domain receptor Human
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  • neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629]
  • This target only has 0 pki data point
  • 0
4 CHEMBL2010872_lig_chart_4 neurotrophic receptor tyrosine kinase 1 Human
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  • neurotrophic receptor tyrosine kinase 2 in Human [GtoPdb: 1818] [UniProtKB: Q16620]
  • This target only has 0 pki data point
  • 0
5 CHEMBL2010872_lig_chart_5 neurotrophic receptor tyrosine kinase 2 Human
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  • TEK receptor tyrosine kinase in Human [GtoPdb: 1842] [UniProtKB: Q02763]
  • This target only has 0 pki data point
  • 0
6 CHEMBL2010872_lig_chart_6 TEK receptor tyrosine kinase Human
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  • BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451]
  • This target only has 0 pki data point
  • 0
7 CHEMBL2010872_lig_chart_7 BLK proto-oncogene, Src family tyrosine kinase Human
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  • mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318]
  • This target only has 0 pki data point
  • 0
8 CHEMBL2010872_lig_chart_8 mitogen-activated protein kinase kinase kinase 7 Human
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  • ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949]
  • This target only has 0 pki data point
  • 0
9 CHEMBL2010872_lig_chart_9 ret proto-oncogene Human
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  • serine/threonine kinase 3 in Human [GtoPdb: 2219] [UniProtKB: Q13188]
  • This target only has 0 pki data point
  • 0
10 CHEMBL2010872_lig_chart_10 serine/threonine kinase 3 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
fibroblast growth factor receptor 1 in Human [GtoPdb: 1808] [UniProtKB: P11362]
GtoPdb - - 7.89 pIC50 13 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948]
GtoPdb - - 8.52 pIC50 3 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb - - 8.4 pIC50 4 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629]
GtoPdb - - 8.52 pIC50 3 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
neurotrophic receptor tyrosine kinase 2 in Human [GtoPdb: 1818] [UniProtKB: Q16620]
GtoPdb - - 8.3 pIC50 5 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
TEK receptor tyrosine kinase in Human [GtoPdb: 1842] [UniProtKB: Q02763]
GtoPdb - - 7.59 pIC50 26 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451]
GtoPdb - - 8.1 pIC50 8 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318]
GtoPdb - - 7.85 pIC50 14 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949]
GtoPdb - - 8.3 pIC50 5 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]
serine/threonine kinase 3 in Human [GtoPdb: 2219] [UniProtKB: Q13188]
GtoPdb - - 7.68 pIC50 21 nM IC50 J Med Chem (2012) 55: 903-13 [PMID:22148921]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]