compound 13a [PMID: 23639540] [Ligand Id: 8155] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2385579 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
| GtoPdb | - | - | 7.27 | pIC50 | 53.4 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of ALK2 (unknown origin) | B | 7.27 | pIC50 | 53.4 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896] | ||||||||
| ChEMBL | Inhibition of ALK4 (unknown origin) | B | 5.23 | pIC50 | 5930 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478] | ||||||||
| ChEMBL | Inhibition of AMPK (unknown origin) | B | 7.4 | pIC50 | 39.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| Bone morphogenetic protein 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384894] [UniProtKB: P21275] | ||||||||
| ChEMBL | Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay | B | 6.85 | pIC50 | 141 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
| GtoPdb | - | - | 7.98 | pIC50 | 10.4 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of ALK3 (unknown origin) | B | 7.98 | pIC50 | 10.4 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238] | ||||||||
| ChEMBL | Inhibition of ALK6 (unknown origin) | B | 7.22 | pIC50 | 60.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| GtoPdb | - | - | 7.22 | pIC50 | 60.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873] | ||||||||
| ChEMBL | Inhibition of BMPR2 (unknown origin) | B | 7.8 | pIC50 | 15.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| GtoPdb | - | - | 7.8 | pIC50 | 15.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023] | ||||||||
| ChEMBL | Inhibition of ALK1 (unknown origin) | B | 7.38 | pIC50 | 42.1 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| GtoPdb | - | - | 7.38 | pIC50 | 42.1 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Inhibition of ALK5 (unknown origin) | B | 4.96 | pIC50 | 10900 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] | ||||||||
| GtoPdb | - | - | 8.86 | pIC50 | 1.37 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of TGFBR2 (unknown origin) | B | 8.86 | pIC50 | 1.37 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| GtoPdb | - | - | 8.77 | pIC50 | 1.68 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of KDR (unknown origin) | B | 8.77 | pIC50 | 1.68 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| AMP kinase in Human [GtoPdb: 1540] | ||||||||
| GtoPdb | - | - | 7.4 | pIC50 | 39.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
