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ChEMBL ligand: CHEMBL2312654 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012] | ||||||||
ChEMBL | Inhibition of CAMK1 (unknown origin) in presence of ATP | B | 5.41 | pIC50 | 3880 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
ChEMBL | Inhibition of CK1-delta (unknown origin) in presence of ATP | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
ChEMBL | Inhibition of CK2 (unknown origin) in presence of ATP | B | 5.12 | pIC50 | 7560 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
cyclin dependent kinase 6/CDK6/cyclin D3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111448] [GtoPdb: 1978] [UniProtKB: P30281, Q00534] | ||||||||
ChEMBL | Inhibition of CDK6/cyclin D3 (unknown origin) in presence of ATP | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
ChEMBL | Inhibition of CDK2/cyclin A (unknown origin) in presence of ATP | B | 5.94 | pIC50 | 1150 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
ChEMBL | Inhibition of CLK1 (unknown origin) in presence of ATP | B | 5.79 | pIC50 | 1630 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] | ||||||||
ChEMBL | Inhibition of ECK (unknown origin) in presence of ATP | B | 5.61 | pIC50 | 2430 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGFR (unknown origin) in presence of ATP | B | 6.23 | pIC50 | 590 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibition of FGFR1 (unknown origin) in presence of ATP | B | 5.77 | pIC50 | 1710 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta (unknown origin) in presence of ATP | B | 5.11 | pIC50 | 7740 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK-beta (unknown origin) in presence of ATP | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
ChEMBL | Inhibition of IKKi (unknown origin) in presence of ATP | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of INSR (unknown origin) in presence of ATP | B | 5.21 | pIC50 | 6180 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of MAPKAP-K2 (unknown origin) in presence of ATP | B | 4.73 | pIC50 | 18570 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of MAPK1/ERK2 (unknown origin) in presence of ATP | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192] | ||||||||
ChEMBL | Inhibition of MAP3K9 (unknown origin) in presence of ATP | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819] | ||||||||
GtoPdb | - | - | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-5 [PMID:23312943] |
ChEMBL | Inhibition of MAP4K4 (unknown origin) in presence of ATP | B | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
myosin light chain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2777] [GtoPdb: 1553] [UniProtKB: Q9H1R3] | ||||||||
ChEMBL | Inhibition of MYLK2 (unknown origin) in presence of ATP | B | 5.31 | pIC50 | 4860 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
selectin P (CD62)/P-selectin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5378] [GtoPdb: 3103] [UniProtKB: P16109] | ||||||||
ChEMBL | Inhibition of P-selectin aggregation in platelet surface (unknown origin) | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of AKT1 (unknown origin) in presence of ATP | B | 5.51 | pIC50 | 3100 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of Aurora-A (unknown origin) in presence of ATP | B | 5.81 | pIC50 | 1550 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of CHK1 (unknown origin) in presence of ATP | B | 5.86 | pIC50 | 1370 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
ChEMBL | Inhibition of CHK2 (unknown origin) in presence of ATP | B | 5.1 | pIC50 | 7970 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2] | ||||||||
ChEMBL | Inhibition of MARK1 (unknown origin) in presence of ATP | B | 5.83 | pIC50 | 1490 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188] | ||||||||
ChEMBL | Inhibition of MST2 (unknown origin) in presence of ATP | B | 6.33 | pIC50 | 470 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289] | ||||||||
ChEMBL | Inhibition of MASK (unknown origin) in presence of ATP | B | 5.42 | pIC50 | 3840 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] | ||||||||
ChEMBL | Inhibition of NEK2 (unknown origin) in presence of ATP | B | 5.6 | pIC50 | 2510 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
ChEMBL | Inhibition of PAK4 (unknown origin) in presence of ATP | B | 5.24 | pIC50 | 5720 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of ABL (unknown origin) in presence of ATP | B | 6.09 | pIC50 | 810 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
ChEMBL | Inhibition of BTK (unknown origin) in presence of ATP | B | 6.02 | pIC50 | 950 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 (unknown origin) in presence of ATP | B | 5.28 | pIC50 | 5300 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK (unknown origin) in presence of ATP | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418] | ||||||||
GtoPdb | - | - | 9.15 | pIC50 | 0.7 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-5 [PMID:23312943] |
ChEMBL | Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATP | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1051-1055 [PMID:23312943] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]