tanomastat [Ligand Id: 6468] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL261932 (BAY 12-9566, BAY-12-9566, BAY-129566, Tanomastat) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-1 (MMP-1). | B | 5.3 | pKi | 5000 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 219-232 [PMID:11754593] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-13 (MMP-13). | B | 5.83 | pKi | 1470 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-2 (MMP-2). | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| GtoPdb | - | - | 8 | pKi | 10 | nM | Ki | Cancer Metastasis Rev (2006) 25: 115-36 [PMID:16680577] |
| ChEMBL | In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2002) 45: 219-232 [PMID:11754593] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-3 (MMP-3). | B | 6.84 | pKi | 143 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | Inhibition of Matrix metalloprotease-3 (MMP-3) in fluorimetric assay | B | 6.87 | pIC50 | 134 | nM | IC50 | J Med Chem (2002) 45: 219-232 [PMID:11754593] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-9 (MMP-9). | B | 6.52 | pKi | 301 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay | B | 6.52 | pIC50 | 301 | nM | IC50 | J Med Chem (2002) 45: 219-232 [PMID:11754593] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
