MMP1 | M10: Matrix metallopeptidase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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  Target has curated data in GtoImmuPdb

Target id: 1628

Nomenclature: MMP1

Family: M10: Matrix metallopeptidase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

This target is also described as a ligand entry: matrix metalloproteinase 1

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 469 11q21-q22 MMP1 matrix metallopeptidase 1
Mouse - 464 9 A1-A2 Mmp1a matrix metallopeptidase 1a (interstitial collagenase)
Rat - 464 8q11 Mmp1 matrix metallopeptidase 1
Previous and Unofficial Names
Collagenase-1 | fibroblast collagenase | matrix metallopeptidase 1a | Mcol-A | CLG | matrix metallopeptidase 1 (interstitial collagenase)
Database Links
Specialist databases
MEROPS M10.001 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cipemastat Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3x10-9 M) [1]
ilomastat Hs Inhibition 8.2 pIC50 4
pIC50 8.2 (IC50 6x10-9 M) [4]
apratastat Hs Inhibition 7.5 pIC50 3
pIC50 7.5 (IC50 3.3x10-8 M) [3]
CGS-27023A Hs Inhibition 7.3 pIC50 5
pIC50 7.3 (IC50 5.6x10-8 M) [5]
Immunopharmacology Comments
Overexpression of MMP-1 degrades extracellular matrix causing damage to the colon mucosa in patients with ulcerative colitis. The MMP-1 promotes secretion of TNFα causing futher damage. Levels of MMP-1 and TNFα correlate with disease severity [6].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050900 leukocyte migration TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0019221 cytokine-mediated signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0050900 leukocyte migration TAS
Immuno Disease Associations
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  Serum level of MMP1 correlates with disease activity in RA.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Epidermolysis bullosa dystrophica, autosomal recessive
Synonyms: Epidermolysis bullosa dystrophica [Disease Ontology: DOID:4959]
Severe generalized recessive dystrophic epidermolysis bullosa [Orphanet: ORPHA79408]
Disease Ontology: DOID:4959
OMIM: 226600
Orphanet: ORPHA79408


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1. Close DR. (2001) Matrix metalloproteinase inhibitors in rheumatic diseases. Ann. Rheum. Dis., 60 Suppl 3: iii62-7. [PMID:11890658]

2. Green MJ, Gough AK, Devlin J, Smith J, Astin P, Taylor D, Emery P. (2003) Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis. Rheumatology (Oxford), 42 (1): 83-8. [PMID:12509618]

3. Levin JI, Chen JM, Laakso LM, Du M, Schmid J, Xu W, Cummons T, Xu J, Jin G, Barone D et al.. (2006) Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg. Med. Chem. Lett., 16 (6): 1605-9. [PMID:16426848]

4. Ma D, Wu W, Yang G, Li J, Li J, Ye Q. (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg. Med. Chem. Lett., 14 (1): 47-50. [PMID:14684295]

5. Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E et al.. (2011) Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem, 46 (7): 2617-29. [PMID:21514700]

6. Wang YD, Mao JW. (2007) Expression of matrix metalloproteinase-1 and tumor necrosis factor-alpha in ulcerative colitis. World J. Gastroenterol., 13 (44): 5926-32. [PMID:17990358]

How to cite this page

M10: Matrix metallopeptidase: MMP1. Last modified on 04/03/2019. Accessed on 14/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,