SP203 [Ligand Id: 6434] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL229429
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
Created with Highcharts 10.3.3ValuesChart context menuAlpha-1a adrenergic receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
Created with Highcharts 10.3.3ValuesChart context menuAlpha-1b adrenergic receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
Created with Highcharts 10.3.3ValuesChart context menuAlpha-2a adrenergic receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
Created with Highcharts 10.3.3ValuesChart context menuAlpha-2b adrenergic receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
Created with Highcharts 10.3.3ValuesChart context menuAlpha-2c adrenergic receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
Created with Highcharts 10.3.3ValuesChart context menuBeta-1 adrenergic receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
Created with Highcharts 10.3.3ValuesChart context menuBeta-2 adrenergic receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
Created with Highcharts 10.3.3ValuesChart context menuDelta opioid receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
Created with Highcharts 10.3.3ValuesChart context menuDopamine D1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
Created with Highcharts 10.3.3ValuesChart context menuDopamine D2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
Created with Highcharts 10.3.3ValuesChart context menuDopamine D3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
Created with Highcharts 10.3.3ValuesChart context menuDopamine D4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • D5 receptor/Dopamine D5 receptor in Human [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
Created with Highcharts 10.3.3ValuesChart context menuDopamine D5 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuDopamine transporterpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
Created with Highcharts 10.3.3ValuesChart context menuHistamine H1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
Created with Highcharts 10.3.3ValuesChart context menuHistamine H2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
Created with Highcharts 10.3.3ValuesChart context menuHistamine H3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • H4 receptor/Histamine H4 receptor in Human [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8]
Created with Highcharts 10.3.3ValuesChart context menuHistamine H4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
Created with Highcharts 10.3.3ValuesChart context menuKappa opioid receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
Created with Highcharts 10.3.3ValuesChart context menuMetabotropic glutamate receptor 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mGlu2 receptor/Metabotropic glutamate receptor 2 in Human [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
Created with Highcharts 10.3.3ValuesChart context menuMetabotropic glutamate receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mGlu4 receptor/Metabotropic glutamate receptor 4 in Human [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833]
Created with Highcharts 10.3.3ValuesChart context menuMetabotropic glutamate receptor 4pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
Created with Highcharts 10.3.3ValuesChart context menuMetabotropic glutamate receptor 5pKd RatpKi RatpIC50 RatpEC50 Rat024681012Highcharts.com
  • mGlu6 receptor/Metabotropic glutamate receptor 6 in Human [ChEMBL: CHEMBL4573] [GtoPdb: 294] [UniProtKB: O15303]
Created with Highcharts 10.3.3ValuesChart context menuMetabotropic glutamate receptor 6pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mGlu8 receptor/Metabotropic glutamate receptor 8 in Human [ChEMBL: CHEMBL3228] [GtoPdb: 296] [UniProtKB: O00222]
Created with Highcharts 10.3.3ValuesChart context menuMetabotropic glutamate receptor 8pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
Created with Highcharts 10.3.3ValuesChart context menuMu opioid receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
Created with Highcharts 10.3.3ValuesChart context menuMuscarinic acetylcholine receptor M1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
Created with Highcharts 10.3.3ValuesChart context menuMuscarinic acetylcholine receptor M2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
Created with Highcharts 10.3.3ValuesChart context menuMuscarinic acetylcholine receptor M3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
Created with Highcharts 10.3.3ValuesChart context menuMuscarinic acetylcholine receptor M4pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
Created with Highcharts 10.3.3ValuesChart context menuMuscarinic acetylcholine receptor M5pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
Created with Highcharts 10.3.3ValuesChart context menuNorepinephrine transporterpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 1a (5-HT1a) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 1b (5-HT1b) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 1d (5-HT1d) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 1e (5-HT1e) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 2a (5-HT2a) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 2b (5-HT2b) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 2c (5-HT2c) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 3 (5-HT3) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 5a (5-HT5a) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 6 (5-HT6) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 7 (5-HT7) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin transporterpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
Created with Highcharts 10.3.3ValuesChart context menuSigma opioid receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Displacement of [3H]prazosin from adrenergic alpha-1A receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL Displacement of [3H]prazosin from adrenergic alpha-1B receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL Displacement of [3H]cholidine from adrenergic alpha2A receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL Displacement of [3H]cholidine from adrenergic alpha-2B receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL Displacement of [3H]cholidine from adrenergic alpha-2C receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Displacement of [125I]pindolol from adrenergic beta-1 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Displacement of [125I]pindolol from adrenergic beta-2 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL Displacement of [3H]DADLE from delta opioid receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL Displacement of [3H]SCH-23390 from dopamine D1 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Displacement of [3H]N-methylspiperone from dopamine D2 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Displacement of [3H]N-methylspiperone from dopamine D3 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Displacement of [3H]N-methylspiperone from dopamine D4 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
ChEMBL Displacement of radiolabeled SKF-38393 from dopamine D5 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL Displacement of [3H]WIN-35428 from DAT B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL Binding affinity to histamine H1 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL Binding affinity to from histamine H2 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL Binding affinity to histamine H3 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
H4 receptor/Histamine H4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8]
ChEMBL Binding affinity to histamine H4 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL Displacement of [3H]bremazocine from kappa opioid receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
ChEMBL Binding affinity at mGluR1 B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
ChEMBL Binding affinity at mGluR2 B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833]
ChEMBL Binding affinity at mGluR4 B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL Displacement of [3H]MPEP from mGluR5 in rat brain B 10.44 pKi 0.04 nM Ki J Med Chem (2011) 54: 901-908 [PMID:21207959]
GtoPdb - - 10.44 pIC50 0.04 nM IC50 J Med Chem (2007) 50: 3256-66 [PMID:17571866]
ChEMBL Displacement of [3H]MPEP from mGluR5 in rat brain membrane B 10.44 pIC50 0.04 nM IC50 J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
mGlu6 receptor/Metabotropic glutamate receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4573] [GtoPdb: 294] [UniProtKB: O15303]
ChEMBL Binding affinity at mGluR6 B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
mGlu8 receptor/Metabotropic glutamate receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3228] [GtoPdb: 296] [UniProtKB: O00222]
ChEMBL Binding affinity at mGluR8 B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL Displacement of [3H]diprenorphine from mu opioid receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL Displacement of [3H]QNB from muscarinic M1 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL Displacement of [3H]QNB from muscarinic M2 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL Displacement of [3H]QNB from muscarinic M3 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL Displacement of [3H]QNB from muscarinic M4 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL Displacement of [3H]QNB from muscarinic M5 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Displacement of [3H]nisoxitine from NET B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Displacement of [3H]8-OH-DPAT from 5HT1A receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL Displacement of [3H]GR-125743 from 5HT1B receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL Displacement of [3H]GR-125743 from 5HT1D receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
ChEMBL Displacement of [3H]5-HT from 5HT1E receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Displacement of [3H]ketanserin from 5HT2A receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Displacement of [3H]LSD from 5HT2B receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Displacement of [3H]mesulergine from 5HT2C receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377, 374, 373, 376, 375] [UniProtKB: A5X5Y0, O95264, P46098, Q70Z44, Q8WXA8]
ChEMBL Displacement of [3H]zacopride from 5HT3 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
ChEMBL Displacement of [3H]LSD from 5HT5A receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Displacement of [3H]LSD from 5HT6 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL Displacement of [3H]LSD from 5HT7 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Displacement of [3H]citalopram from SERT B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL Binding affinity to sigma1 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 3256-3266 [PMID:17571866]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]