A-119637 [Ligand Id: 490] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL268758 (A-119637) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| ChEMBL | Binding affinity for human Alpha-1A adrenergic receptor | B | 8.58 | pKi | 2.63 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| ChEMBL | Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active | B | 8.59 | pKi | 2.6 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 657-664 [PMID:15664832] |
| GtoPdb | - | - | 8.6 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130] | ||||||||
| ChEMBL | Binding affinity towards bovine Alpha-1A adrenergic receptor | B | 9.56 | pKi | 0.27 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
| ChEMBL | In vitro functional activity at Alpha-1A adrenergic receptor in rat vas deferens | B | 8.07 | pKd | 8.51 | nM | Kd | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| GtoPdb | - | - | 8.6 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| ChEMBL | Binding affinity towards rat Alpha-1A adrenergic receptor | B | 8.61 | pKi | 2.43 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| ChEMBL | Binding affinity towards human Alpha-1B adrenergic receptor | B | 8.33 | pKi | 4.66 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] | ||||||||
| ChEMBL | In vitro functional activity at Alpha-1B adrenergic receptor in rat spleen | F | 8.69 | pKd | 2.04 | nM | Kd | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
| ChEMBL | Binding affinity towards human Alpha-1D adrenergic receptor | B | 9.6 | pKi | 0.25 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| GtoPdb | - | - | 9.6 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] | ||||||||
| ChEMBL | In vitro functional activity at Alpha-1D adrenergic receptor in rat aorta | B | 10.6 | pKd | 0.03 | nM | Kd | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| ChEMBL | Binding affinity towards rat Alpha-1D adrenergic receptor | B | 9.67 | pKi | 0.21 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| GtoPdb | - | - | 9.7 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
| ChEMBL | Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptor | B | 7.11 | pKi | 77.8 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328] | ||||||||
| ChEMBL | Ancillary Binding affinity towards rat alpha-2B receptor | B | 7.15 | pKi | 71 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
| ChEMBL | Ancillary Binding affinity to cloned human Alpha-2C adrenergic receptor | B | 7.13 | pKi | 74.7 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | Ancillary Binding affinity to rat Dopamine receptor D1 | B | 5.22 | pKi | 6090 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Ancillary Binding affinity towards rat Dopamine receptor D2 | B | 7.3 | pKi | 50 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
