cisapride [Ligand Id: 240] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1729 (Prepulsid quicklet, Propulsid quicksolv, R-51619, Cisapride, R-51,619, Cisapride monohydrate, Alimix, Propulsid, Prepulsid)
  • Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
  • 7.42
1 CHEMBL1729_lig_chart_1 Alpha-1a adrenergic receptor BovineRat
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  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
  • This target only has 1 pki data point
  • 8.06
2 CHEMBL1729_lig_chart_2 Alpha-1b adrenergic receptor Rat
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  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
  • This target only has 1 pki data point
  • 7.03
3 CHEMBL1729_lig_chart_3 Alpha-1d adrenergic receptor Human
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909]
  • 7.52
4 CHEMBL1729_lig_chart_4 Alpha-2a adrenergic receptor HumanRat
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
  • 6.28
5 CHEMBL1729_lig_chart_5 Alpha-2b adrenergic receptor Human
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
  • This target only has 1 pki data point
  • 6.95
6 CHEMBL1729_lig_chart_6 Alpha-2c adrenergic receptor Human
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  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 0 pki data point
  • 0
7 CHEMBL1729_lig_chart_7 Beta-1 adrenergic receptor Human
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • This target only has 0 pki data point
  • 0
8 CHEMBL1729_lig_chart_8 Beta-2 adrenergic receptor Human
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  • CYP2D6/Cytochrome P450 2D6 in Human [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
  • This target only has 0 pki data point
  • 0
9 CHEMBL1729_lig_chart_9 Cytochrome P450 2D6 Human
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  • CYP3A4/Cytochrome P450 3A4 in Human [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684]
  • This target only has 0 pki data point
  • 0
10 CHEMBL1729_lig_chart_10 Cytochrome P450 3A4 Human
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
  • Dopamine D1 receptor in Bovine [ChEMBL: CHEMBL2967] [UniProtKB: Q95136]
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
  • This target only has 1 pki data point
  • 5.77
11 CHEMBL1729_lig_chart_11 Dopamine D1 receptor HumanBovineRat
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • Dopamine D2 receptor in Bovine [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
  • 6.64
12 CHEMBL1729_lig_chart_12 Dopamine D2 receptor HumanBovineRat
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
  • 7.31
13 CHEMBL1729_lig_chart_13 Dopamine D3 receptor Human
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  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 1 pki data point
  • 6.86
14 CHEMBL1729_lig_chart_14 HERG Human
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  • hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
  • This target only has 0 pki data point
  • 0
15 CHEMBL1729_lig_chart_15 HMG-CoA reductase Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
  • 5.79
16 CHEMBL1729_lig_chart_16 Serotonin 1a (5-HT1a) receptor HumanRat
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • Serotonin 2a (5-HT2a) receptor in Bovine [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89]
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
  • 0
17 CHEMBL1729_lig_chart_17 Serotonin 2a (5-HT2a) receptor HumanBovineRat
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • 7.28
18 CHEMBL1729_lig_chart_18 Serotonin 2b (5-HT2b) receptor Human
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • This target only has 1 pki data point
  • 6.4
19 CHEMBL1729_lig_chart_19 Serotonin 2c (5-HT2c) receptor Human
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20 CHEMBL1729_lig_chart_20 Serotonin 3 (5-HT3) receptor HumanRat
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Rat [ChEMBL: CHEMBL2411] [GtoPdb: 373] [UniProtKB: P35563]
  • 5.82
21 CHEMBL1729_lig_chart_21 Serotonin 3a (5-HT3a) receptor HumanRat
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  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
  • 5-HT4 receptor in Mouse [GtoPdb: 9] [UniProtKB: P97288]
  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758]
  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
  • 7.7
22 CHEMBL1729_lig_chart_22 Serotonin 4 (5-HT4) receptor HumanMouseRatGuinea pig
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • 5-HT7 receptor in Mouse [GtoPdb: 12] [UniProtKB: P32304]
  • 5.8
23 CHEMBL1729_lig_chart_23 Serotonin 7 (5-HT7) receptor HumanMouse
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 1 pki data point
  • 6.69
24 CHEMBL1729_lig_chart_24 Serotonin transporter Human
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • This target only has 1 pki data point
  • 6.38
25 CHEMBL1729_lig_chart_25 Sigma opioid receptor Human
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  • Nav1.5/Sodium channel protein type V alpha subunit in Human [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
  • This target only has 0 pki data point
  • 0
26 CHEMBL1729_lig_chart_26 Sodium channel protein type V alpha subunit Human
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  • Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
  • This target only has 0 pki data point
  • 0
27 CHEMBL1729_lig_chart_27 Voltage-dependent L-type calcium channel subunit alpha-1C Guinea pig
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL Binding affinity was evaluated by Alpha-1 adrenergic receptor in calf cortex by displacing prazosin B 7.5 pKd 7.5 - pKD J. Med. Chem. (1995) 38: 2326-2330 [PMID:7608898]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) B 7.31 pKi 49 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL The ability to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat whole brain B 7.52 pKi 30 nM Ki J. Med. Chem. (1992) 35: 1486-1489 [PMID:1573641]
ChEMBL DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) B 6.92 pIC50 120 nM IC50 DrugMatrix in vitro pharmacology data
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) B 8.06 pKi 8.65 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) B 7.8 pIC50 16 nM IC50 DrugMatrix in vitro pharmacology data
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) B 7.03 pKi 93 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) B 6.72 pIC50 189 nM IC50 DrugMatrix in vitro pharmacology data
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) B 6.18 pKi 666 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) B 5.75 pIC50 1777 nM IC50 DrugMatrix in vitro pharmacology data
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909]
ChEMBL Compound was evaluated for the binding affinity at Alpha adrenergic receptor B 7.52 pKi 30 nM Ki J. Med. Chem. (1995) 38: 2326-2330 [PMID:7608898]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) B 6.28 pKi 524 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) B 5.94 pIC50 1148 nM IC50 DrugMatrix in vitro pharmacology data
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) B 6.95 pKi 113 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) B 6.11 pIC50 780 nM IC50 DrugMatrix in vitro pharmacology data
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Binding affinity to adrenergic beta-1 receptor B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2006) 49: 1125-1139 [PMID:16451077]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Binding affinity to adrenergic beta-2 receptor B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2006) 49: 1125-1139 [PMID:16451077]
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) B 7.15 pIC50 70 nM IC50 DrugMatrix in vitro pharmacology data
CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684]
ChEMBL DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) B 6.52 pIC50 300 nM IC50 DrugMatrix in vitro pharmacology data
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL Binding affinity to dopamine receptor D1 B 5.77 pIC50 1700 nM IC50 J. Med. Chem. (2006) 49: 1125-1139 [PMID:16451077]
Dopamine D1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136]
ChEMBL Binding affinity was evaluated by Dopamine receptor D1 agonism in the calf striatum by displacing SCH 23390 B 5.2 pKd 5.2 - pKD J. Med. Chem. (1995) 38: 2326-2330 [PMID:7608898]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata B 5.77 pKi 1700 nM Ki J. Med. Chem. (1992) 35: 1486-1489 [PMID:1573641]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) B 6.8 pKi 158 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) B 6.33 pIC50 473 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Binding affinity to dopamine receptor D2 B 6.64 pIC50 227 nM IC50 J. Med. Chem. (2006) 49: 1125-1139 [PMID:16451077]
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
ChEMBL Binding affinity was evaluated by Dopamine receptor D2 agonism in the calf striatum by displacing spiperone B 6.5 pKd 6.5 - pKD J. Med. Chem. (1995) 38: 2326-2330 [PMID:7608898]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand B 6.64 pKi 227 nM Ki J. Med. Chem. (2003) 46: 702-715 [PMID:12593651]
ChEMBL The ability to inhibit [3H]domperidone binding to dopamine receptor D2 in rat striata B 6.64 pKi 227 nM Ki J. Med. Chem. (1992) 35: 1486-1489 [PMID:1573641]
ChEMBL Displacement of [3H]spiroperidol from D2 dopamine receptor B 6.17 pIC50 680 nM IC50 J. Med. Chem. (1994) 37: 1320-1325 [PMID:8176710]
ChEMBL Inhibitory activity against dopamine receptor D2 by 3H ligand binding experiments. B 6.41 pIC50 390 nM IC50 J. Med. Chem. (1991) 34: 616-624 [PMID:1995885]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) B 7.31 pKi 49 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) B 6.84 pIC50 144 nM IC50 DrugMatrix in vitro pharmacology data
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) B 6.86 pKi 139.4 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of human ERG Y652A mutant expressed in HEK293 cells by whole cell patch clamp method B 5.57 pIC50 2690 nM IC50 J. Med. Chem. (2009) 52: 1630-1638 [PMID:19260734]
ChEMBL Inhibition of human ERG F656A mutant expressed in HEK293 cells by whole cell patch clamp method B 5.77 pIC50 1710 nM IC50 J. Med. Chem. (2009) 52: 1630-1638 [PMID:19260734]
ChEMBL DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) B 6.77 pIC50 170.1 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of human ERG expressed in CHO cells by Qpatch assay B 6.82 pIC50 150 nM IC50 Eur J Med Chem (2017) 127: 72-86 [PMID:28038328]
ChEMBL Inhibition of human ERG S624A mutant expressed in HEK293 cells by whole cell patch clamp method B 6.92 pIC50 120 nM IC50 J. Med. Chem. (2009) 52: 1630-1638 [PMID:19260734]
ChEMBL Inhibition of human ERG overexpressed in CHO cells by Qpatch method B 7.01 pIC50 98 nM IC50 Bioorg. Med. Chem. (2015) 23: 5881-5890 [PMID:26211462]
ChEMBL Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay B 7.1 pIC50 80 nM IC50 J. Med. Chem. (2014) 57: 3687-3706 [PMID:24564525]
ChEMBL Inhibitory activity against Potassium channel HERG B 7.33 pIC50 47 nM IC50 J. Med. Chem. (2003) 46: 2017-2022 [PMID:12747773]
ChEMBL Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1 B 7.35 pIC50 45 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 1829-1835 [PMID:12729675]
ChEMBL Inhibition of human ERG expressed in CHO cells assessed as whole cell current by patch clamp assay B 7.4 pIC50 40 nM IC50 J. Med. Chem. (2015) 58: 4506-4520 [PMID:25992974]
GtoPdb - - 7.4 pIC50 44.5 nM IC50 FEBS Lett (1997) 417: 28-32 [PMID:9395068]
ChEMBL Inhibition of human Potassium channel HERG expressed in mammalian cells B 7.4 pIC50 39.81 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique B 7.4 pIC50 39.81 nM IC50 Bioorg. Med. Chem. (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL Inhibitory concentration against potassium channel HERG B 7.4 pIC50 39.81 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL Inhibition of wild-type human ERG expressed in HEK293 cells by whole cell patch clamp method B 8 pIC50 10 nM IC50 J. Med. Chem. (2009) 52: 1630-1638 [PMID:19260734]
ChEMBL Inhibition of human ERG B 8.17 pIC50 6.76 nM IC50 Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626]
ChEMBL Inhibition of human ERG channel B 8.17 pIC50 6.7 nM