Top ▲

SLC7 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

SLC7 family members may be divided into two major groups: cationic amino acid transporters (CATs) and glycoprotein-associated amino acid transporters (gpaATs).

Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y+), apparently as an exchange mechanism. These transporters are sensitive to inhibition by N-ethylmaleimide.

Transporters

892
Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

CAT1 (High affinity cationic amino acid transporter 1 / SLC7A1) C Show summary »

CAT2 (Low affinity cationic amino acid transporter 2 / SLC7A2) C Show summary »


Target Id 892
Nomenclature Low affinity cationic amino acid transporter 2
Systematic nomenclature SLC7A2
Common abbreviation CAT2
Previous and unofficial names ATRC2 | Cat2a | Cat2b | cationic amino acid transporter-2A | low affinity cationic amino acid transporter 2 | solute carrier family 7 (cationic amino acid transporter y+ system) member 2 | solute carrier family 7 member 2 | Tea | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | solute carrier family 7 (cationic amino acid transporter, y system), member 2 | solute carrier family 7 (cationic amino acid transporter
Genes SLC7A2 (Hs), Slc7a2 (Mm), Slc7a2 (Rn)
Ensembl ID ENSG00000003989 (Hs), ENSMUSG00000031596 (Mm), ENSRNOG00000011016 (Rn)
UniProtKB AC P52569 (Hs), P18581 (Mm), B5D5N9 (Rn)
Bioparadigms SLC Tables SLC7A2 (Hs)
RESOLUTE SLC7A2 (Hs)
Substrates
L-arginine
L-lysine
L-ornithine
L-histidine

CAT3 (Cationic amino acid transporter 3 / SLC7A3) C Show summary »

CAT4 (Cationic amino acid transporter 4 / SLC7A4) Show summary »

Probable cationic amino acid transporter / SLC7A14 Show summary »

LAT1 (L-type amino acid transporter 1 / SLC7A5) C Show summary » More detailed page go icon to follow link

LAT2 (L-type amino acid transporter 2 / SLC7A8) C Show summary »

y+LAT1 (y+L amino acid transporter 1 / SLC7A7) C Show summary »

y+LAT2 (y+L amino acid transporter 2 / SLC7A6) C Show summary »

b0,+AT (b0,+-type amino acid transporter 1 / SLC7A9) C Show summary »

Asc-1 (Asc-type amino acid transporter 1 / SLC7A10) C Show summary »

xCT (Cystine/glutamate transporter / SLC7A11) C Show summary »

AGT1 / SLC7A13 C Show summary »

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.