Top ▲

DNA topoisomerase 4

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 3227

Nomenclature: DNA topoisomerase 4

Family: Bacterial protein targets

Quaternary Structure: Subunits
DNA topoisomerase 4 subunit A
DNA topoisomerase 4 subunit B
Quaternary Structure Comments
DNA topoisomerase 4 is a tetrameric enzyme, consisting of DNA topoisomerase 4 A (parC) and B (parE) subunits assembled into an A2B2 complex.
Previous and Unofficial Names Click here for help
Topoisomerase IV | Topo IV
Database Links Click here for help
ChEMBL Target

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BWC0977 Small molecule or natural product Click here for species-specific activity table E.coli Inhibition 8.0 pIC50
pIC50 8.0 (IC50 1x10-8 M)
General Comments
DNA topoisomerase 4 (also know as Topoisomerase IV) is a Type II DNA topoisomerase [1-2]. It is one of two enzymes of this subclass found in bacteria, the other being DNA gyrase. DNA topoisomerase 4 decatenates interlinked daughter chromosomes following DNA replication [3]. It catalyzes ATP-dependent breakage, passage and rejoining of double-stranded DNA.

References

Show »

1. Kato J, Nishimura Y, Imamura R, Niki H, Hiraga S, Suzuki H. (1990) New topoisomerase essential for chromosome segregation in E. coli. Cell, 63 (2): 393-404. [PMID:2170028]

2. Kato J, Suzuki H, Ikeda H. (1992) Purification and characterization of DNA topoisomerase IV in Escherichia coli. J Biol Chem, 267 (36): 25676-84. [PMID:1334483]

3. Zechiedrich EL, Khodursky AB, Cozzarelli NR. (1997) Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli. Genes Dev, 11 (19): 2580-92. [PMID:9334322]

How to cite this page

Bacterial protein targets: DNA topoisomerase 4. Last modified on 04/08/2023. Accessed on 31/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3227.