Fc fragment of IgG receptor IIIa | CD molecules | IUPHAR Guide to IMMUNOPHARMACOLOGY

Fc fragment of IgG receptor IIIa

Target id: 3017

Nomenclature: Fc fragment of IgG receptor IIIa

Systematic Nomenclature: CD16A

Family: CD molecules, Immunoglobulin like domain containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Fc fragment of IgG receptor IIIa has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 359 1q23.3 FCGR3A Fc fragment of IgG receptor IIIa
Mouse 1 249 1 H3; 1 78.53 cM Fcgr4 Fc receptor, IgG, low affinity IV
Rat 1 249 13q24 Fcgr3a Fc fragment of IgG receptor IIIa
Gene and Protein Information Comments
Alternatively spliced transcript variants encoding different isoforms have been reported for the human gene.
Previous and Unofficial Names
FCγRIIIa | FcRIIIA | low affinity immunoglobulin gamma Fc region receptor III-A
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Antibodies
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Antibody Sp. Action Affinity Units Reference
AFM13 Hs Binding 9.1 – 9.4 pKd 1
pKd 9.1 – 9.4 (Kd 8.4x10-10 – 3.9x10-10 M) [1]
Description: Binding to CD16a 158V and 158F proteins by SPR.
Immunopharmacology Comments
The FCGR3A gene is expressed by natural killer (NK) cells. The protein product (CD16A or FcγRIIIa) is an integral peptide-tethered membrane glycoprotein. FcγRIIIa is a low-affinity receptor for IgG Fc and is involved in removing antigen-antibody complexes from the circulation and antibody-dependent responses.
FcγRIIIa is being exploited for drug development, specifically as a NK cell-engager to mediate NK effector cell killing of cancer cells. See for example AFM13, a tetravalent bispecific Fv peptide construct that simultaneously engages FcγRIIIa and CD30 on CD30-expressing malignancies such as Hodgkin lymphoma cells.
General Comments
FcγRIIIa is an integral membrane glycoprotein anchored through a transmembrane peptide to the surface of natural killer (NK) cells.

References

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1. Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, Knackmuss SH, Kiprijanov S, Little M, Zhukovsky EA. (2014) A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. MAbs, 6 (3): 728-39. [PMID:24670809]

How to cite this page

CD molecules: Fc fragment of IgG receptor IIIa. Last modified on 29/08/2018. Accessed on 19/10/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3017.