GSK180   Click here for help

GtoPdb Ligand ID: 9007

Synonyms: inhibitor A1 [PMID: 28604669]
PDB Ligand
Compound class: Synthetic organic
Comment: GSK180 is a potent and selective competitive inhibitor of kynurenine 3-monooxygenase (KMO) [1], an enzyme involved in tryptophan metabolism. The structure is a derivative of the enzyme substrate kynurenine.
Currently the only X-ray crystal structure available is for GSK180 in complex with the Pseudomonas fluorescens KMO homologue (PDB ID 5FN0).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 72.44
Molecular weight 274.98
XLogP 1.92
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC(=O)CCn1c(=O)oc2c1cc(Cl)c(c2)Cl
Isomeric SMILES OC(=O)CCn1c(=O)oc2c1cc(Cl)c(c2)Cl
InChI InChI=1S/C10H7Cl2NO4/c11-5-3-7-8(4-6(5)12)17-10(16)13(7)2-1-9(14)15/h3-4H,1-2H2,(H,14,15)
InChI Key MIGAKMWKMLYGJX-UHFFFAOYSA-N
Bioactivity Comments
In biochemical assays GSK180 shows negligible activity against other enzymes in the tryptophan pathway, or against a panel of >50 unrelated proteins.
In vivo, GSK180 provides therapeutic protection against multiple organ dysfunction syndrome (MODS) in a rat model of acute pancreatitis [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kynurenine 3-monooxygenase Primary target of this compound Hs Inhibitor Inhibition 8.2 pIC50 - 1
⤷ pIC50 8.2 [1]
Description: Biochemical assay using human KMO expressed as a GST-fusion protein in a baculovirus expression system.