dienogest   Click here for help

GtoPdb Ligand ID: 7654

Synonyms: dienogestrel | STS-557
Approved drug
dienogest is an approved drug (FDA (2010))
Compound class: Synthetic organic
Comment: Note that the 2010 FDA approval is for the fixed-mixture combination oral contraceptive detailed in the Clinical data tab.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 61.09
Molecular weight 311.19
XLogP 1.98
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES N#CCC1(O)CCC2C1(C)CCC1=C3CCC(=O)C=C3CCC21
Isomeric SMILES N#CC[C@]1(O)CC[C@@H]2[C@]1(C)CCC1=C3CCC(=O)C=C3CC[C@@H]21
InChI InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1
InChI Key AZFLJNIPTRTECV-FUMNGEBKSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2010))
IUPAC Name Click here for help
2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile
International Nonproprietary Names Click here for help
INN number INN
5286 dienogest
Synonyms Click here for help
dienogestrel | STS-557
Database Links Click here for help
ChEBI CHEBI:70708
ChEMBL Ligand CHEMBL1201864
DrugCentral Ligand 871
GtoPdb PubChem SID 223365989
PubChem CID 68861
Search Google for chemical match using the InChIKey AZFLJNIPTRTECV-FUMNGEBKSA-N
Search Google for chemicals with the same backbone AZFLJNIPTRTECV
Search PubMed clinical trials dienogest
Search PubMed titles dienogest
Search PubMed titles/abstracts dienogest
UniChem Compound Search for chemical match using the InChIKey AZFLJNIPTRTECV-FUMNGEBKSA-N
UniChem Connectivity Search for chemical match using the InChIKey AZFLJNIPTRTECV-FUMNGEBKSA-N
Wikipedia Dienogest