dienogest   Click here for help

GtoPdb Ligand ID: 7654

Synonyms: dienogestrel | STS-557
Approved drug
dienogest is an approved drug (FDA (2010))
Compound class: Synthetic organic
Comment: Note that the 2010 FDA approval is for the fixed-mixture combination oral contraceptive detailed in the Clinical data tab.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 61.09
Molecular weight 311.19
XLogP 1.98
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES N#CCC1(O)CCC2C1(C)CCC1=C3CCC(=O)C=C3CCC21
Isomeric SMILES N#CC[C@]1(O)CC[C@@H]2[C@]1(C)CCC1=C3CCC(=O)C=C3CC[C@@H]21
InChI InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1
InChI Key AZFLJNIPTRTECV-FUMNGEBKSA-N
No information available.
Summary of Clinical Use Click here for help
Fixed-mixture combination drugs containing dienogest and estradiol valerate are used as combined oral contraceptives (COCs) to prevent pregnancy, or may also be used to reduce heavy menstrual bleeding. The COCs include brands such as Natazia®, Qlaira® and Delestrogen®. Such drugs are covered by PubChem CID 9874560.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
COCs reduce the risk of pregnancy by primarily supressing ovulation, but also effect changes which render the cervix and endometrium hostile to sperm.