dolichol phosphate   Click here for help

GtoPdb Ligand ID: 3214

Abbreviated name: DP
Compound class: Metabolite
Comment: Mammalian dolichol phosphate varies in molecular size from 18 to 21 isoprene units [2]. The structure shown here is representative of dolichol phosphate with 2 isoprene groups.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 76.57
Molecular weight 304.18
XLogP 3.88
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CC(CCC=C(CCC=C(C)C)C)CCOP(=O)(O)O
Isomeric SMILES CC(CC/C=C(/CCC=C(C)C)\C)CCOP(=O)(O)O
InChI InChI=1S/C15H29O4P/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-19-20(16,17)18/h7,9,15H,5-6,8,10-12H2,1-4H3,(H2,16,17,18)/b14-9+
InChI Key DZHSRPJGCZHWOM-NTEUORMPSA-N
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
mevalonate kinase Hs Inhibitor Competitive 4.1 pKi - 1
pKi 4.1 (Ki 8.3x10-5 M) [1]
Description: recombinant enzyme expressed in E coli cells. Spectrophotometric assay
Conditions: pH 7.0, 25°C. Saturating concentrations of substrates, 0.16-5mM ATP