Synonyms: geranyl pyrophosphate | GPP | neryl pyrophosphate
Compound class:
Metabolite
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Barnard GF, Popják G. (1981)
Human liver prenyltransferase and its characterization. Biochim Biophys Acta, 661 (1): 87-99. [PMID:7295734] |
2. Glickman JF, Schmid A. (2007)
Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay. Assay Drug Dev Technol, 5 (2): 205-14. [PMID:17477829] |
3. Hinson DD, Chambliss KL, Toth MJ, Tanaka RD, Gibson KM. (1997)
Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. J Lipid Res, 38 (11): 2216-23. [PMID:9392419] |
4. Qiu Y, Li D. (2006)
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett, 8 (6): 1013-6. [PMID:16524256] |
5. Qiu Y, Li D. (2006)
Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. Biochim Biophys Acta, 1760 (7): 1080-7. [PMID:16626865] |
6. Runquist M, Ericsson J, Thelin A, Chojnacki T, Dallner G. (1994)
Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans-prenyltransferase. J Biol Chem, 269 (8): 5804-9. [PMID:8119922] |