[111In,90Y]DOTA-TOC   Click here for help

GtoPdb Ligand ID: 2059

Synonyms: YIII-DOTA-TOC | YIII-DOTA-Tyr3-octreotide | YIII-DOTA-TOC [1]
 Ligand is labelled  Ligand is radioactive
Compound class: Peptide
Comment: Synthetic peptide octreotide (SMS 201,995), modified at position 3 of the amino acid sequence, conjugated with DOTA and labelled with yttrium (90Y) and indium (111In). The exact structure of this ligand is not specified in the reference. For the structures of DOTA and octreotide see the individual ligand pages. 'TOC' is formed by the substitution of phenyalanine residue 3 in octreotide with tyrosine (Tyr).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
SST2 receptor Hs Agonist Full agonist 7.9 pIC50 - 1
⤷ pIC50 7.9 [1]
SST5 receptor Hs Agonist Full agonist 6.7 pIC50 - 1
⤷ pIC50 6.7 [1]
SST3 receptor Hs Agonist Full agonist 6.4 pIC50 - 1
⤷ pIC50 6.4 [1]