NPT520-34   Click here for help

GtoPdb Ligand ID: 13271

Synonyms: compound 1 [WO2019246454]
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: NPT520-34 is a small molecule clinical lead with potential efficacy in neurodegenerative disorders [2]. Preclinical evidence shows that NPT520-34 clears neurotoxic protein aggregates and reduces inflammation. The direct molecular target(s) of NPT520-34 have not been identified, but experimental data support enhanced protein clearance by autophagy. Screening against a broad panel of protein targets identified NPT520-34 as an inhibitor of the solute carrier organic ion transporter organic anion transporter 3 (OAT3; SLC22A8), and this is confirmed by claim of this compound as an anti-neurodegeneration OAT3 inhibitor in patent WO2019246454A1 [1]. The physiological relevance of this remains to be confirmed.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 102.24
Molecular weight 419.83
XLogP 3.05
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=C(C=CC(=C1)S(=O)(=O)C2=CC=C(C(=C2)C(F)(F)F)Cl)N3C=NNC3=S
Isomeric SMILES FC(F)(F)C1=C(Cl)C=CC(=C1)S(=O)(=O)C2=CC=C(C=C2)N3C=NNC3=S
InChI InChI=1S/C15H9ClF3N3O2S2/c16-13-6-5-11(7-12(13)15(17,18)19)26(23,24)10-3-1-9(2-4-10)22-8-20-21-14(22)25/h1-8H,(H,21,25)
InChI Key BJWHWZOMLHXKPF-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
4-[4-[4-chloro-3-(trifluoromethyl)phenyl]sulfonylphenyl]-1H-1,2,4-triazole-5-thione
Synonyms Click here for help
compound 1 [WO2019246454]
Database Links Click here for help
DrugBank Ligand DB17920
GtoPdb PubChem SID 491300053
PubChem CID 139507438
Search Google for chemical match using the InChIKey BJWHWZOMLHXKPF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BJWHWZOMLHXKPF
UniChem Compound Search for chemical match using the InChIKey BJWHWZOMLHXKPF-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey BJWHWZOMLHXKPF-UHFFFAOYSA-N