Synonyms: AMG 757 | AMG-757 | AMG757 | Imdelltra® | tarlatamab-dlle
tarlatamab is an approved drug (FDA (2024))
Compound class:
Antibody
Comment: Tarlatamab (AMG 757) is a bispecific T cell engager (BiTE®) type anti-Delta-like ligand 3 (DLL3) monoclonal antibody [5-6]. It co-engages DLL3 on cancer cells and CD3E on T cells to promote T cell-mediated tumour lysis. The rationale for investigating DLL3 as a cancer drug target is reviewed in [3].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
No information available. |
Summary of Clinical Use |
Tarlatamab (AMG 757) was progressed to clinical evaluation for the treatment of advanced solid tumours [1,7]. The FDA granted accelerated approval for the treatment of extensive stage small cell lung cancer (progressing during/following platinum-based chemotherapy) in May 2024 [4]. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT05740566 | Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer | Phase 3 Interventional | Amgen | ||
NCT03319940 | Study Evaluating Safety, Tolerability and Pharmacokinetics (PK) of Tarlatamab in Adults With Small Cell Lung Cancer (SCLC) | Phase 1 Interventional | Amgen | 6 | |
NCT05060016 | A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC) | Phase 2 Interventional | Amgen | 2 |