Synonyms: compound 23-h [PMID: 37458396] | YXG158
Compound class:
Synthetic organic
Comment: YXG-158 is a steroid analogue that has dual functions as an androgen receptor degrader and CYP17A1 (steroid 17-α hydroxylase; androgen synthetase) inhibitor [1]. It is a preclinical lead for the treatment of enzalutamide-resistant prostate cancer.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
DC50 for AR degradation is 1280 nM [1]. YXG-158 is effective against wild-type and mutated androgen receptors that are found in prostate tumours with acquired resistance to AR antagonist therapies. |
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