Synonyms: EN-67
Compound class:
Synthetic organic
Comment: EN67 is a molecular glue type protein degrader [1]. It is a derivative of EN450, and like its predecsor EN67 forms a covalent bond with the allosteric C111 residue on UBE2D E2 ubiquitin-conjugating enzymes. Direct interaction with the UBE2D2 isozyme has been demonstrated.
EN67 has been conjudated to the BRD4 inhibitor (+)-JQ1, to generate a PROTAC class degrader (named NF90), which demonstrates that E2 ubiquitin ligase components can be recruited by such molecules to promote degradation of neo-substrates, in addition to the many previously reported recruiters that target E3 components of the ubiquitin-proteasome system. |
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Classification | |
Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name |
N-[[3-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl]prop-2-enamide |
Synonyms |
EN-67 |
Database Links | |
GtoPdb PubChem SID | 479821427 |
PubChem CID | 132362390 |
Search Google for chemical match using the InChIKey | YHMCRSNQSHQSSZ-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | YHMCRSNQSHQSSZ |
UniChem Compound Search for chemical match using the InChIKey | YHMCRSNQSHQSSZ-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | YHMCRSNQSHQSSZ-UHFFFAOYSA-N |