Compound class:
Synthetic organic
Comment: This compound is a KRAS-SOS1 interaction inhibitor that was designed for potential to treat KRAS-driven cancers [1]. It binds directly to SOS1 to disrupt the protein-protein interaction, and this action blocks guanine nucleotide exchange on KRAS and reduces KRAS activation.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
1-((R)-11-(((R)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethyl)amino)-9-methyl-1,2,3,4,4a,5-hexahydropyrazino[1′,2′:4,5][1,4]oxazino[3,2-g]quinazoline-3-carbonyl)cyclopropane-1-carbonitrile |
Database Links | |
GtoPdb PubChem SID | 473153844 |
PubChem CID | 165437863 |
Search Google for chemical match using the InChIKey | KKFFOOWORPUAJB-NVXWUHKLSA-N |
Search Google for chemicals with the same backbone | KKFFOOWORPUAJB |
UniChem Compound Search for chemical match using the InChIKey | KKFFOOWORPUAJB-NVXWUHKLSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | KKFFOOWORPUAJB-NVXWUHKLSA-N |