ZWB67   Click here for help

GtoPdb Ligand ID: 12229

Compound class: Antibody
Comment: ZWB67 is a bispecific monoclonal antibody that simultaneously targets the tumour antigen claudin 18.2 (CLDN18.2) and the CD3e molecule on effector T cells [1]. It uses the VH and VL domains from the anti-hCD3e from Amgen's CD3e/PSMA bispecific pasotuxizumab. Affinity for CD3e is low by design. ZWB67 is intended to induce an anti-tumour immune response against CLDN18.2+ve cancers [1]. ZWB67 has demonstrated in vivo efficacy in a mice bearing MC-38-hCLDN18.2 xenograft tumours.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
Bioactivity Comments
Binds to hCLND18.2 expressed in HEK293T cells with an EC50 of ~2 μg/mL [1]. Activation of the NF-κB signaling pathway by ZWB67 (via CD3e engagement) is dependent upon binding to CLDN18.2; there is no activation in CLDN18.2-negative cells.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD3e Hs Antibody Binding 8.0 pKd - 1
⤷ pKd 8.0 (Kd 1x10-8 M) [1]
claudin 18 Hs Antibody Binding - - - 1
⤷ [1]
Description: EC50 ~2 μg/mL in cells expressing CLDN18.2