varokibart   Click here for help

GtoPdb Ligand ID: 12187

Immunopharmacology Ligand
Compound class: Antibody
Comment: Varokibart is an IgG4λ, fully human anti-IL-5 monoclonal antibody that was developed for potential anti-inflammatory action. The '-bart' stem indicates that it is an engineered antibody. The amino acid sequences for varokibart's heavy and light chains are claimed in Cephalon, Inc.'s patent WO2018119016A1, as SEQ IDs 20 and 19 respectively [1]. These two peptide chains generate the antibody disclosed as 3A5.046 therein.
Teva acquired Cephalon in 2011, and from review of Teva's development pipeline it is possible that varokibart is their clinical candidate TEV-48574. Although the mechanism of action of TEV-48574 has not been formally declared, it was initially tested for anti-asthma efficacy, which is a predictable indication for an anti-IL-5 agent.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
12309 varokibart
Database Links Click here for help
GtoPdb PubChem SID 472319309
Search PubMed clinical trials varokibart
Search PubMed titles varokibart
Search PubMed titles/abstracts varokibart