Synonyms: 20-Hydroxyecdysone | beta-Ecdysone | Crustecdysone | Ecdysterone | Sarconeos
Compound class:
Natural product
Comment: BIO101 is pharmaceutical grade 20-hydroxyecdysone, the latter being a natural product found in the Asparagus filicinus fern, the trematode Trichobilharzia ocellata, and other organisms. Its activity as a non-peptidic activator of the class A orphan GPCR MAS1 has been proposed to offer potential clinical utility to counteract dysregulation of the renin-angiotensin system (RAS) in patients with COVID-19 respiratory failure [1-2]. Given the role of ACE2 in the RAS, and the disturbance of ACE2 function that likely ensues when SARS-CoV-2 spike protein binds to ACE2, it is feasible that the RAS will be dysregulated in COVID-19, and that ameliorating this disruption through targeted pharmacological intervention might be of potential clinical benefit.
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Classification | |
Compound class | Natural product |
Synonyms |
20-Hydroxyecdysone | beta-Ecdysone | Crustecdysone | Ecdysterone | Sarconeos |
Database Links | |
GtoPdb PubChem SID | 464244128 |
LIPID MAPS | LMST01010209 |
PubChem CID | 5459840 |
RCSB PDB Ligand | 20E |
Search Google for chemical match using the InChIKey | NKDFYOWSKOHCCO-YPVLXUMRSA-N |
Search Google for chemicals with the same backbone | NKDFYOWSKOHCCO |
UniChem Compound Search for chemical match using the InChIKey | NKDFYOWSKOHCCO-YPVLXUMRSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NKDFYOWSKOHCCO-YPVLXUMRSA-N |