Synonyms: 20-Hydroxyecdysone | beta-Ecdysone | Crustecdysone | Ecdysterone | Sarconeos
Compound class:
Natural product
Comment: BIO101 is pharmaceutical grade 20-hydroxyecdysone, the latter being a natural product found in the Asparagus filicinus fern, the trematode Trichobilharzia ocellata, and other organisms. Its activity as a non-peptidic activator of the class A orphan GPCR MAS1 has been proposed to offer potential clinical utility to counteract dysregulation of the renin-angiotensin system (RAS) in patients with COVID-19 respiratory failure [1-2]. Given the role of ACE2 in the RAS, and the disturbance of ACE2 function that likely ensues when SARS-CoV-2 spike protein binds to ACE2, it is feasible that the RAS will be dysregulated in COVID-19, and that ameliorating this disruption through targeted pharmacological intervention might be of potential clinical benefit.
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References |
1. Lafont R, Serova M, Didry-Barca B, Raynal S, Guibout L, Dinan L, Veillet S, Latil M, Dioh W, Dilda PJ. (2021)
20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor. J Mol Endocrinol, 68 (2): 77-87. [PMID:34825653] |
2. Latil M, Camelo S, Veillet S, Lafont R, Dilda PJ. (2021)
Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients. Drug Discov Today, 26 (5): 1311-1318. [PMID:33609783] |