FGF-21

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Ligands
FGF-21 (Human)

GtoPdb Ligand ID: 11721

Synonyms: fibroblast growth factor 21

Compound class: Endogenous peptide in human, mouse or rat

Comment: FGF21 is a mitogen that is involved in the migration and differentiation of cells that are of mesodermal or neuroectodermal origin, and in metabolic regulation [2]. Klotho beta (KLB) appears to be required for FGF21's metabolic activity [3]. The peptide sequence provided here includes the signal peptide (MDSDETGFEHSGLWVSVLAGLLLGACQA).

Species: Human

Summary
Biological activity
References
Structure

Bioactivity Comments
FGF21 can signal through FGFR1-3 that are bound by βKlotho. This mechanism increases glucose uptake in adipocytes that express FGFR1 [3]. FGF21 is reported to actively participate in skin wound healing [1].

Bioactivity Comments

FGF21 can signal through FGFR1-3 that are bound by βKlotho. This mechanism increases glucose uptake in adipocytes that express FGFR1 [3]. FGF21 is reported to actively participate in skin wound healing [1].