FSH deglycosylated α/β   Click here for help

GtoPdb Ligand ID: 1158

Compound class: Peptide
Comment: Based on the naturally occuring peptide FSH, this synthetic analogue consists of two synthetic subunits in which the glycosylated asparagine residues of the natural sequence are replaced by glycine residues
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Flack MR, Froehlich J, Bennet AP, Anasti J, Nisula BC. (1994)
Site-directed mutagenesis defines the individual roles of the glycosylation sites on follicle-stimulating hormone.
J Biol Chem, 269 (19): 14015-20. [PMID:8188681]
2. Keene JL, Nishimori K, Galway AB, Hsueh AJW, Boime I. (1994)
Recombinant deglycosylated human FSH is an antagonist of human FSH action in cultured rat granulosa cells.
Endocrinology Journal, 2: 175-179.