Synonyms: example 52 [WO2017132661A2] | ONC-212
Compound class:
Synthetic organic
Comment: ONC212 is an imipridone-based Class A GPCR modulating compound. It is claimed to selectively target the orphan GPCR and tumour suppressor GPR132, at which it acts as an agonist and activator of Gαq signaling [1-2]. It does not engage dopamine D2 receptors. ONC212 exerts anti-tumour activity via oral and intraperitoneal delivery in xenograft mice.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
ONC212 has demonstrated anti-cancer efficacy against various tumour types that are represented in the NCI60 cancer cell line panel [1]. |
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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