Synonyms: Mulpleta® | S-888711 | S888711
lusutrombopag is an approved drug (Japan (2015), FDA (2018), EMA (2019))
Compound class:
Synthetic organic
Comment: Lusutrombopag is an orally bioavailable, nonpeptidyl, small molecule thrombopoietin (TPO) receptor agonist [4] that was developed by Shionogi in Japan. It was the second TPO receptor agonist to receive FDA approval in 2018 (avatrombopag was the first).
Lusutrombopag demonstrates antibacterial activity in vitro with potential to be repurposed as a treatment for infections caused by drug-resistant Enterococcus spp. [3]. |
|
Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (Japan (2015), FDA (2018), EMA (2019)) |
IUPAC Name |
(E)-3-[2,6-dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid |
International Nonproprietary Names | |
INN number | INN |
9410 | lusutrombopag |
Synonyms |
Mulpleta® | S-888711 | S888711 |
Database Links | |
Specialist databases | |
Antibiotic DB | Lusutrombopag |
Other databases | |
BindingDB Ligand | 430660 |
CAS Registry No. | 1110766-97-6 (source: PubChem) |
ChEBI | CHEBI:136051 |
ChEMBL Ligand | CHEMBL2107831 |
DrugBank Ligand | DB13125 |
DrugCentral Ligand | 5059 |
GtoPdb PubChem SID | 375973220 |
PubChem CID | 49843517 |
Search Google for chemical match using the InChIKey | NOZIJMHMKORZBA-KJCUYJGMSA-N |
Search Google for chemicals with the same backbone | NOZIJMHMKORZBA |
Search PubMed clinical trials | lusutrombopag |
Search PubMed titles | lusutrombopag |
Search PubMed titles/abstracts | lusutrombopag |
UniChem Compound Search for chemical match using the InChIKey | NOZIJMHMKORZBA-KJCUYJGMSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NOZIJMHMKORZBA-KJCUYJGMSA-N |