Protein kinase N (PKN) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

PKN1 (protein kinase N1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1520

Nomenclature

protein kinase N1

Common abbreviation

PKN1

Previous and unofficial names

PAK1 | PRK1 | PRKCL1 | protein kinase C-like 1 | protease-activated kinase 1 | protein kinase PKN | Stk3 | DBK | protein kinase C-related kinase 1

Genes

PKN1 (Hs), Pkn1 (Mm), Pkn1 (Rn)

Ensembl ID

ENSG00000123143 (Hs), ENSMUSG00000057672 (Mm), ENSRNOG00000004131 (Rn)

UniProtKB AC

Q16512 (Hs), P70268 (Mm), Q63433 (Rn)

EC number

2.7.11.13

Comment

PKN family members are activated by Rho, PIP₃ and PDK1 [1]

PKN2 (protein kinase N2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1521

Nomenclature

protein kinase N2

Common abbreviation

PKN2

Previous and unofficial names

Genes

PKN2 (Hs), Pkn2 (Mm), Pkn2 (Rn)

Ensembl ID

ENSG00000065243 (Hs), ENSMUSG00000004591 (Mm), ENSRNOG00000011317 (Rn)

UniProtKB AC

Q16513 (Hs), Q8BWW9 (Mm), O08874 (Rn)

EC number

2.7.11.13

Comment

PKN family members are activated by Rho, PIP₃ and PDK1 [1]

PKN3 (protein kinase N3) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1522

Nomenclature

protein kinase N3

Common abbreviation

PKN3

Previous and unofficial names

Protein kinase PKN-beta | PKNbeta

Genes

PKN3 (Hs), Pkn3 (Mm), Pkn3 (Rn)

Ensembl ID

ENSG00000160447 (Hs), ENSMUSG00000026785 (Mm), ENSRNOG00000025892 (Rn)

UniProtKB AC

Q6P5Z2 (Hs), Q8K045 (Mm)

EC number

2.7.11.13

Comment

PKN family members are activated by Rho, PIP₃ and PDK1 [1]

References

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How to cite this family page

Database page citation:

Protein kinase N (PKN) family. Accessed on 26/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=601.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.