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Interleukin-1 receptor-associated kinase (IRAK) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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The IRAK family consists of four members, IRAK1, IRAK2, IRAK3 (also known as IRAK-M) and IRAK4. Only IRAK1 and IRAK4 have verified kinase activity [3]. Whilst IRAKs 1, 2 and 4 are ubiquitously expressed, IRAK3 expression is restricted to monocytes and macrophages. IRAKs are key components of the IL-1 receptor and Toll-like receptor signalling pathways of the innate immune response.


Targets of relevance to immunopharmacology are highlighted in blue

IRAK1 (interleukin 1 receptor associated kinase 1) Show summary » More detailed page

IRAK2 (interleukin 1 receptor associated kinase 2) Show summary » More detailed page

IRAK3 (interleukin 1 receptor associated kinase 3) Show summary » More detailed page

IRAK4 (interleukin 1 receptor associated kinase 4) Show summary » More detailed page


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How to cite this family page

Database page citation:

Interleukin-1 receptor-associated kinase (IRAK) family. Accessed on 10/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.