Neurotensin receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

GtoImmuPdb view: ON   

Overview

« Hide More detailed introduction

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [4]) are activated by the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at the NTS2 receptor. [3H]Neurotensin (human, mouse, rat) and [125I]neurotensin (human, mouse, rat) may be used to label NTS1 and NTS2 receptors at 0.1-0.3 and 3-5 nM concentrations respectively.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

NTS1 receptor C Show summary » More detailed page

NTS2 receptor C Show summary » More detailed page

Comments

Show »

Further reading

Show »

References

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Jean Mazella, Philippe Sarret, Jean-Pierre Vincent. Neurotensin receptors. Accessed on 22/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=47.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.