The SLC2 family transports D-glucose, D-fructose, inositol (e.g. myo-inositol) and related hexoses. Three classes of glucose transporter can be identified, separating GLUT1-4 and 14, GLUT6, 8, 10 and 12; and GLUT5, 7, 9 and 11. Modelling suggests a 12 TM membrane topology, with intracellular termini, with functional transporters acting as homodimers or homotetramers.

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* Key recommended reading is highlighted with an asterisk

* Augustin R. (2010) The protein family of glucose transport facilitators: It's not only about glucose after all. IUBMB Life, 62 (5): 315-33. [PMID:20209635]

* Holman GD. (2020) Structure, function and regulation of mammalian glucose transporters of the SLC2 family. Pflugers Arch, 472 (9): 1155-1175. [PMID:32591905]

* Klip A, Sun Y, Chiu TT, Foley KP. (2014) Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. Am J Physiol, Cell Physiol, 306 (10): C879-86. [PMID:24598362]

* Leney SE, Tavaré JM. (2009) The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets. J Endocrinol, 203 (1): 1-18. [PMID:19389739]

* Mueckler M, Thorens B. (2013) The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med, 34 (2-3): 121-38. [PMID:23506862]

Uldry M, Thorens B. (2004) The SLC2 family of facilitated hexose and polyol transporters. Pflugers Arch, 447 (5): 480-9. [PMID:12750891]

Wolking S, Becker F, Bast T, Wiemer-Kruel A, Mayer T, Lerche H, Weber YG. (2014) Focal epilepsy in glucose transporter type 1 (Glut1) defects: case reports and a review of literature. J Neurol, 261 (10): 1881-6. [PMID:25022942]