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Target has curated data in GtoImmuPdb
Target id: 2735
Nomenclature: E1A binding protein p300
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 2414 | 22q13.2 | EP300 | E1A binding protein p300 | |
Mouse | - | 2412 | 15 E1 | Ep300 | E1A binding protein p300 | |
Rat | - | - | 7q34 | Ep300 | E1A binding protein p300 |
Previous and Unofficial Names ![]() |
histone acetyltransferase p300 | KAT3B |
Database Links ![]() |
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Alphafold | Q09472 (Hs) |
CATH/Gene3D | 1.10.1630.10, 1.20.1020.10, 1.20.920.10 |
ChEMBL Target | CHEMBL3784 (Hs) |
Ensembl Gene | ENSG00000100393 (Hs), ENSMUSG00000055024 (Mm), ENSRNOG00000065659 (Rn), ENSRNOG00000000190 (Rn) |
Entrez Gene | 2033 (Hs), 328572 (Mm), 170915 (Rn) |
Human Protein Atlas | ENSG00000100393 (Hs) |
KEGG Gene | hsa:2033 (Hs), mmu:328572 (Mm), rno:170915 (Rn) |
OMIM | 602700 (Hs) |
Pharos | Q09472 (Hs) |
RefSeq Nucleotide | NM_001429 (Hs), NM_177821 (Mm) |
RefSeq Protein | NP_001420 (Hs), NP_808489 (Mm) |
SynPHARM | 79942 (in complex with SGC-CBP30) |
UniProtKB | Q09472 (Hs) |
Wikipedia | EP300 (Hs) |
Selected 3D Structures ![]() |
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Download all structure-activity data for this target as a CSV file
Activators | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. PMID: 26261308 |
Immuno Process Associations | |||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Balasubramanyam K, Altaf M, Varier RA, Swaminathan V, Ravindran A, Sadhale PP, Kundu TK. (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem, 279 (32): 33716-26. [PMID:15155757]
2. Balasubramanyam K, Swaminathan V, Ranganathan A, Kundu TK. (2003) Small molecule modulators of histone acetyltransferase p300. J Biol Chem, 278 (21): 19134-40. [PMID:12624111]
3. Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, Ranga U, Kundu TK. (2004) Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J Biol Chem, 279 (49): 51163-71. [PMID:15383533]
4. Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H et al.. (2010) Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol, 17 (5): 471-82. [PMID:20534345]
5. Chatterjee S, Mizar P, Cassel R, Neidl R, Selvi BR, Mohankrishna DV, Vedamurthy BM, Schneider A, Bousiges O, Mathis C et al.. (2013) A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice. J Neurosci, 33 (26): 10698-712. [PMID:23804093]
6. Choi KC, Jung MG, Lee YH, Yoon JC, Kwon SH, Kang HB, Kim MJ, Cha JH, Kim YJ, Jun WJ et al.. (2009) Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res, 69 (2): 583-92. [PMID:19147572]
7. Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T et al.. (2012) Histone recognition and large-scale structural analysis of the human bromodomain family. Cell, 149 (1): 214-31. [PMID:22464331]
8. Gallenkamp D, Gelato KA, Haendler B, Weinmann H. (2014) Bromodomains and their pharmacological inhibitors. ChemMedChem, 9 (3): 438-64. [PMID:24497428]
9. Lau OD, Kundu TK, Soccio RE, Ait-Si-Ali S, Khalil EM, Vassilev A, Wolffe AP, Nakatani Y, Roeder RG, Cole PA. (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell, 5 (3): 589-95. [PMID:10882143]
10. Ravindra KC, Selvi BR, Arif M, Reddy BA, Thanuja GR, Agrawal S, Pradhan SK, Nagashayana N, Dasgupta D, Kundu TK. (2009) Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin. J Biol Chem, 284 (36): 24453-64. [PMID:19570987]
11. SGC. I-CBP112 A CREBBP/EP300-selective chemical probe. Accessed on 04/08/2023. Modified on 04/08/2023. thesgc.org, https://www.thesgc.org/chemical-probes/I-CBP112
Non-enzymatic BRD containing proteins: E1A binding protein p300. Last modified on 04/08/2023. Accessed on 27/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2735.