Synonyms: CBPD409 | compound 25 [PMID: 38530938]
Compound class:
Synthetic organic
Comment: CBPD-409 is an orally bioactive PROTAC degrader that targets the CBP (CREB binding protein) and p300 (E1A binding protein p300) proteins [1]. It binds to the target proteins using a GNE-049-derived moiety, and a thalidomide ligand is used to interact with the cereblon E3 ubiquitin ligase.
CBP and p300 are bromodomain and histone acetyltransferase (HAT) domain-containing proteins that act as androgen receptor transcriptional coactivators. CBPD-409 was designed to disrupt CBP/p300-induced androgen receptor expression in prostate cancers. |
|
Classification | |
Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms |
CBPD409 | compound 25 [PMID: 38530938] |
Database Links | |
GtoPdb PubChem SID | 496703271 |
PubChem CID | 171364440 |
Search Google for chemical match using the InChIKey | CXJGNQXWKVPWMM-KEQSSBIPSA-N |
Search Google for chemicals with the same backbone | CXJGNQXWKVPWMM |
UniChem Compound Search for chemical match using the InChIKey | CXJGNQXWKVPWMM-KEQSSBIPSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | CXJGNQXWKVPWMM-KEQSSBIPSA-N |