The interferon receptor family includes receptors for type I (α, β κ and ω) and type II (γ) interferons. There are at least 13 different genes encoding IFN-α subunits in a cluster on human chromosome 9p22: α1 (IFNA1, P01562), α2 (IFNA2, P01563), α4 (IFNA4, P05014), α5 (IFNA5, P01569), α6 (IFNA6, P05013), α7 (IFNA7, P01567), α8 (IFNA8, P32881), α10 (IFNA10, P01566), α13 (IFNA13, P01562), α14 (IFNA14, P01570), α16 (IFNA16, P05015), α17 (IFNA17, P01571) and α21 (IFNA21, P01568).

* Key recommended reading is highlighted with an asterisk

* Kotenko SV, Durbin JE. (2017) Contribution of type III interferons to antiviral immunity: location, location, location. J Biol Chem, 292 (18): 7295-7303. [PMID:28289095]

* Lazear HM, Schoggins JW, Diamond MS. (2019) Shared and Distinct Functions of Type I and Type III Interferons. Immunity, 50 (4): 907-923. DOI: 10.1016/j.immuni.2019.03.025 [PMID:30995506]

* Ng CT, Mendoza JL, Garcia KC, Oldstone MB. (2016) Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes. Cell, 164 (3): 349-52. [PMID:26824652]

* Schreiber G. (2017) The molecular basis for differential type I interferon signaling. J Biol Chem, 292 (18): 7285-7294. [PMID:28289098]

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