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Quaternary Structure: Complexes |
Interleukin-4 receptor type I |
Interleukin-4 receptor type II |
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 825 | 16p12.1 | IL4R | interleukin 4 receptor | |
Mouse | 1 | 810 | 7 68.94 cM | Il4ra | interleukin 4 receptor, alpha | |
Rat | 1 | 801 | 1q36 | Il4r | interleukin 4 receptor |
Previous and Unofficial Names |
CD124 | IL-4 receptor alpha chain | interleukin 4 receptor, alpha |
Database Links | |
Alphafold | P24394 (Hs), P16382 (Mm), Q63257 (Rn) |
CATH/Gene3D | 2.60.40.10 |
ChEMBL Target | CHEMBL3580490 (Hs) |
Ensembl Gene | ENSG00000077238 (Hs), ENSMUSG00000030748 (Mm), ENSRNOG00000015441 (Rn) |
Entrez Gene | 3566 (Hs), 16190 (Mm), 25084 (Rn) |
Human Protein Atlas | ENSG00000077238 (Hs) |
KEGG Gene | hsa:3566 (Hs), mmu:16190 (Mm), rno:25084 (Rn) |
OMIM | 147781 (Hs) |
Pharos | P24394 (Hs) |
UniProtKB | P24394 (Hs), P16382 (Mm), Q63257 (Rn) |
Wikipedia | IL4R (Hs) |
Download all structure-activity data for this target as a CSV file
Antibodies | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). A gain-of-function mutation in IL4R has been associated with atopy, enhanced B cell isotype switching from mu to epsilon and therefore elevated IgE levels [1]. This subunit is the molecular target of the investigational monoclonal antibody dupilumab, that is in clinical trial as a therapy for atopic allergic conditions and nasal polyposis. |
Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||||||||
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1. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. (1997) The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med, 337 (24): 1720-5. [PMID:9392697]
2. Martin JH, Huang TT, Fairhurst JL, Papadopoulos NJ. (2009) Cytokine specific immunoglobulin for use in diagnosis, prevention and treatment ,of cell proliferative, inflammatory, allergic, respiratory, autoimmune and arthritic disorders. Patent number: US7608693. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 02/10/2006. Publication date: 27/10/2009.
3. Soriano A, Lozano F, Oliva H, García F, Nomdedéu M, De Lazzari E, Rodríguez C, Barrasa A, Lorenzo JI, Del Romero J et al.. (2005) Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS. Immunogenetics, 57 (9): 644-54. [PMID:16189667]
IL-2 receptor family: Interleukin-4 receptor subunit α. Last modified on 11/04/2017. Accessed on 03/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1697.