Interleukin-4 receptor subunit α | IL-2 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-4 receptor subunit α

  Target has curated data in GtoImmuPdb

Target id: 1697

Nomenclature: Interleukin-4 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Contents:

Quaternary Structure: Complexes
Interleukin-4 receptor type I
Interleukin-4 receptor type II
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 800 16p12.1-p11.2 IL4R interleukin 4 receptor
Mouse 1 785 7 68.94 cM Il4ra interleukin 4 receptor, alpha
Rat 1 776 1q36 Il4r interleukin 4 receptor
Previous and Unofficial Names
CD124 | IL-4 receptor alpha chain | interleukin 4 receptor, alpha
Database Links
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL3580490 (Hs)
Ensembl Gene ENSG00000077238 (Hs), ENSMUSG00000030748 (Mm), ENSRNOG00000015441 (Rn)
Entrez Gene 3566 (Hs), 16190 (Mm), 25084 (Rn)
Human Protein Atlas ENSG00000077238 (Hs)
KEGG Gene hsa:3566 (Hs), mmu:16190 (Mm), rno:25084 (Rn)
OMIM 147781 (Hs)
UniProtKB P24394 (Hs), P16382 (Mm), Q63257 (Rn)
Wikipedia IL4R (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
dupilumab Hs Binding 11.1 pIC50 2
⤷ pIC50 11.1 (IC50 8.8x10-12 M) [2]
Description: Value derived from an ELISA-based solution competition assay.
Immunopharmacology Comments
IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). A gain-of-function mutation in IL4R has been associated with atopy, enhanced B cell isotype switching from mu to epsilon and therefore elevated IgE levels [1]. This subunit is the molecular target of the investigational monoclonal antibody dupilumab, that is in clinical trial as a therapy for atopic allergic conditions and nasal polyposis.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004913 interleukin-4 receptor activity TAS
GO:0019221 cytokine-mediated signaling pathway TAS
click arrow to show/hide IEA associations
GO:0090197 positive regulation of chemokine secretion IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002532 production of molecular mediator involved in inflammatory response IEA
GO:0043032 positive regulation of macrophage activation IEA
GO:0043306 positive regulation of mast cell degranulation IEA
GO:0045626 negative regulation of T-helper 1 cell differentiation IEA
GO:0045630 positive regulation of T-helper 2 cell differentiation IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0016064 immunoglobulin mediated immune response IEA
GO:0045626 negative regulation of T-helper 1 cell differentiation IEA
GO:0045630 positive regulation of T-helper 2 cell differentiation IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0016064 immunoglobulin mediated immune response IEA
GO:0045626 negative regulation of T-helper 1 cell differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002639 positive regulation of immunoglobulin production IEA
GO:0043032 positive regulation of macrophage activation IEA
GO:0043306 positive regulation of mast cell degranulation IEA
GO:0045626 negative regulation of T-helper 1 cell differentiation IEA
GO:0045630 positive regulation of T-helper 2 cell differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045626 negative regulation of T-helper 1 cell differentiation IEA
GO:0045630 positive regulation of T-helper 2 cell differentiation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045626 negative regulation of T-helper 1 cell differentiation IEA
GO:0045630 positive regulation of T-helper 2 cell differentiation IEA
GO:0090197 positive regulation of chemokine secretion IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0043032 positive regulation of macrophage activation IEA
GO:0043306 positive regulation of mast cell degranulation IEA
GO:0045626 negative regulation of T-helper 1 cell differentiation IEA
GO:0045630 positive regulation of T-helper 2 cell differentiation IEA
Clinically-Relevant Mutations and Pathophysiology
Disease:  Human immunodeficiency virus type 1, susceptibility to
Synonyms: Human immunodeficiency virus infectious disease [Disease Ontology: DOID:526]
Disease Ontology: DOID:526
OMIM: 609423
Orphanet: ORPHA319269
Role:  A polymorphism in IL4R (I50V) is associated with slower progression to AIDs in HIV-positive individuals.
References:  3
Disease:  IgE responsiveness, atopic; IGER
OMIM: 147050

References

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1. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. (1997) The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N. Engl. J. Med., 337 (24): 1720-5. [PMID:9392697]

2. Martin JH, Huang TT, Fairhurst JL, Papadopoulos NJ. (2009) Cytokine specific immunoglobulin for use in diagnosis, prevention and treatment ,of cell proliferative, inflammatory, allergic, respiratory, autoimmune and arthritic disorders. Patent number: US7608693. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 02/10/2006. Publication date: 27/10/2009.

3. Soriano A, Lozano F, Oliva H, García F, Nomdedéu M, De Lazzari E, Rodríguez C, Barrasa A, Lorenzo JI, Del Romero J et al.. (2005) Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS. Immunogenetics, 57 (9): 644-54. [PMID:16189667]

How to cite this page

IL-2 receptor family: Interleukin-4 receptor subunit α. Last modified on 11/04/2017. Accessed on 20/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1697.