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This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 441 | |
Name: | Human immunodeficiency virus type 1, susceptibility to | |
Associated with: | 8 targets |
Synonyms |
Human immunodeficiency virus infectious disease |
Database Links |
Disease Ontology:
DOID:526 OMIM: 609423 Orphanet: ORPHA319269 |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖CCR2 |
CCR5 |
CX3CR1 |
chemerin receptor 1 | |
References: | 1 |
Interleukin-4 receptor subunit α | |
Role: | A polymorphism in IL4R (I50V) is associated with slower progression to AIDs in HIV-positive individuals. |
References: | 2 |
TLR3 |
TLR7 |
TLR9 |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Human immunodeficiency virus type 1, susceptibility to
1. Mårtensson UE, Fenyö EM, Olde B, Owman C. (2006) Characterization of the human chemerin receptor--ChemR23/CMKLR1--as co-receptor for human and simian immunodeficiency virus infection, and identification of virus-binding receptor domains. Virology, 355 (1): 6-17. [PMID:16904155]
2. Soriano A, Lozano F, Oliva H, García F, Nomdedéu M, De Lazzari E, Rodríguez C, Barrasa A, Lorenzo JI, Del Romero J et al.. (2005) Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS. Immunogenetics, 57 (9): 644-54. [PMID:16189667]