abatacept   Click here for help

GtoPdb Ligand ID: 6891

Synonyms: BMS-188667 | CTLA4-IgG4m | Orencia® | RG-1046 | RG-2077
Approved drug Immunopharmacology Ligand
abatacept is an approved drug (FDA (2005), EMA (2005))
Compound class: Peptide or derivative
Comment: Abatacept is a recombinant protein fusing the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) [3]. In essence, abatacept is a CTLA-4 mimetic, that enhances CTLA-4's inhibitory signal to T cells, thereby down-modulating T cell mediated inflammation.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: abatacept

Classification Click here for help
Compound class Peptide or derivative
Ligand families/groups Immune checkpoint modulators
Approved drug? Yes (FDA (2005), EMA (2005))
International Nonproprietary Names Click here for help
INN number INN
8495 abatacept
Synonyms Click here for help
BMS-188667 | CTLA4-IgG4m | Orencia® | RG-1046 | RG-2077
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 212
Other databases
ChEMBL Ligand CHEMBL1201823 (Hs)
DrugBank Ligand DB01281
GtoPdb PubChem SID 178103473
PubChem SID 135355129
Search PubMed clinical trials abatacept
Search PubMed titles abatacept
Search PubMed titles/abstracts abatacept
Wikipedia Abatacept