abatacept [Ligand Id: 6891] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1201823 (Abatacept, Abatacept (genetical recombination), BMS-188667, RG-2077, Orencia, CTLA4-IgG4m, RG-1046, Orencia ClickJect)
  • CD80 in Human [GtoPdb: 2744] [UniProtKB: P33681]
There should be some charts here, you may need to enable JavaScript!
  • CD86 in Human [GtoPdb: 2745] [UniProtKB: P42081]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CD80 in Human [GtoPdb: 2744] [UniProtKB: P33681]
GtoPdb Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept. - 7.92 pKd ~12 nM Kd Expert Rev Clin Immunol (2013) 9: 599-621 [PMID:23899231];
J. Exp. Med. (1991) 174: 561-9 [PMID:1714933]
CD86 in Human [GtoPdb: 2745] [UniProtKB: P42081]
GtoPdb Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept. - 7.92 pKd ~12 nM Kd Expert Rev Clin Immunol (2013) 9: 599-621 [PMID:23899231];
J. Exp. Med. (1991) 174: 561-9 [PMID:1714933]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]