abatacept [Ligand Id: 6891] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201823 (Abatacept, Abatacept (genetical recombination), Abatacept recombinant, BMS-188667, CTLA4-IGG4M, Orencia, Orencia clickject, RG-1046, RG-2077)
  • CD80 in Human [GtoPdb: 2744] [UniProtKB: P33681]
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  • CD86 in Human [GtoPdb: 2745] [UniProtKB: P42081]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CD80 in Human [GtoPdb: 2744] [UniProtKB: P33681]
GtoPdb Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept. - 7.92 pKd ~12 nM Kd Expert Rev Clin Immunol (2013) 9: 599-621 [PMID:23899231];
J Exp Med (1991) 174: 561-9 [PMID:1714933]
CD86 in Human [GtoPdb: 2745] [UniProtKB: P42081]
GtoPdb Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept. - 7.92 pKd ~12 nM Kd Expert Rev Clin Immunol (2013) 9: 599-621 [PMID:23899231];
J Exp Med (1991) 174: 561-9 [PMID:1714933]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]