abatacept [Ligand Id: 6891] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201823 (Abatacept, Abatacept (genetical recombination), Abatacept recombinant, BMS-188667, CTLA4-IGG4M, Orencia, Orencia clickject, RG-1046, RG-2077)
  • CD80 in Human [GtoPdb: 2744] [UniProtKB: P33681]
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  • CD86 in Human [GtoPdb: 2745] [UniProtKB: P42081]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CD80 in Human [GtoPdb: 2744] [UniProtKB: P33681]
GtoPdb Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept. - 7.92 pKd ~12 nM Kd Expert Rev Clin Immunol (2013) 9: 599-621 [PMID:23899231];
J Exp Med (1991) 174: 561-9 [PMID:1714933]
CD86 in Human [GtoPdb: 2745] [UniProtKB: P42081]
GtoPdb Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept. - 7.92 pKd ~12 nM Kd Expert Rev Clin Immunol (2013) 9: 599-621 [PMID:23899231];
J Exp Med (1991) 174: 561-9 [PMID:1714933]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]