Synonyms: 5alpha-Tetrahydrocorticosterone | allotetrahydrocorticosterone
Compound class:
Synthetic organic
Comment: 5α-tetrahydrocorticosterone (5αTHB) is an endogenous steroid with anti-inflammatory action [2]. In in vivo studies topically applied 5αTHB was less angiostatic and caused less skin thinning than the endogenous glucocorticoid/mineralocorticoid receptor agonists cortisol and corticosterone. It is proposed that 5αTHB's anti-inflammatory effects are mediated by mechanisms that are distinct from those of conventional glucocorticoids [1].
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